General Information |
| Summary |
This is a Phase 1 dose-finding study of FT536 monotherapy and in combination with monoclonal antibodies. |
| Description |
This is a Phase 1 dose-finding study of FT536 given in combination with a monoclonal antibody following lymphodepletion in subjects with advanced solid tumors. The study will consist of a dose-escalation stage and an expansion stage where participants will be enrolled into indication-specific cohorts. |
| Clinical trials phase |
Phase 1 |
| Start date (estimated) |
2022-05-31 |
| End date (estimated) |
2027-04-30 |
| Clinical feature |
| Label |
Advanced Malignant Solid Neoplasm |
| Link |
http://purl.obolibrary.org/obo/NCIT_C129707 |
| Description |
A malignant solid neoplasm that has spread extensively to other anatomic sites or is no longer responding to treatment. |
|
Administrative Information |
| NCT number |
NCT05395052 |
| ICTRP weblink |
https://trialsearch.who.int/Trial2.aspx?TrialID=NCT05395052 |
| Other study identifiers |
|
| Source weblink |
https://clinicaltrials.gov/ct2/show/NCT05395052 |
| Public contact |
| Email |
clinical@fatetherapeutics.com |
| Public email |
clinical@fatetherapeutics.com |
| First name |
Rebecca |
| Last name |
Reynolds |
| Phone |
+1 (0)858-875-1800 |
| Country |
|
|
| Sponsors |
Fate Therapeutics
|
Cells |
| Which differentiated cell type is used |
| Label |
natural killer cell |
| Link |
http://purl.obolibrary.org/obo/CL_0000623 |
| Description |
A lymphocyte that can spontaneously kill a variety of target cells without prior antigenic activation via germline encoded activation receptors and also regulate immune responses via cytokine release and direct contact with other cells. |
|
Recruitment |
| Recruitment Status |
Recruiting |
| Estimated number of participants |
322 |
