An open-label, single-center, first-in-human study to evaluate the safety, tolerability and activity of autologous human induced pluripotent stem cell derived endothelial cells (hiPSC-ECs) in patients with peripheral artery disease

Clinical trials phase

Not applicable

Start date (estimated)

2024-12-20

End date (estimated)

2028-08-13

Clinical feature

Label	peripheral artery disease
Link	http://purl.obolibrary.org/obo/DOID_0050830
Description	An artery disease that is characterized by build up of plaque in the arteries that carry blood to your head, organs, and limbs.

ICTRP weblink

Other study identifiers

Name	4-2024-0775
Description	(Unique Protocol ID)

Name	KCT0010071

Source weblink

Which differentiated cell type is used

Label	endothelial cell
Link	http://purl.obolibrary.org/obo/CL_0000115
Description	An endothelial cell comprises the outermost layer or lining of anatomical structures and can be squamous or cuboidal. In mammals, endothelial cell has vimentin filaments and is derived from the mesoderm.; From FMA: 9.07.2001: Endothelial cell has always been classified as a kind of epithelial cell, specifically a squamous cell but that is not true. First, endothelial cell can either be squamous or cuboidal (e.g. high-endothelial cell) and secondly, it has different embryological derivation (mesodermal) than a true epithelial cell (ectodermal and endodermal). The basis for present classification is the fact that it comprises the outermost layer or lining of anatomical structures (location-based) but a better structural basis for the differentia is the cytoskeleton of the cell. Endothelial cell has vimentin filaments while an epithelial cell has keratin filaments. [Onard].

Recruitment Status

Not yet recruiting

Estimated number of participants