A Study of transplantation of autologous induced pluripotent stem cell (iPSC) derived retinal pigment epithelium (RPE) cell sheet in subjects with exudative age related macular degeneration

General Information

Description In this trial of retinal pigment epithelium (RPE) replacement, the aim will be to evaluate the safety and feasibility/efficacy of treating subjects with exudative age-related macular degeneration (AMD) by transplanting autologous iPSC derived RPE sheets.
Clinical trials phase Other
Start date (estimated) 2013-10-02
End date (estimated) 2019-02-28
Clinical feature
Label age related macular degeneration
Link http://purl.obolibrary.org/obo/DOID_10871
Description A degeneration of macula and posterior pole that is characterized by a loss of vision in the center of the visual field (the macula) resulting from damage to the retina and resulting in blurring of the sharp central vision.; OMIM mapping confirmed by DO. [SN].

Administrative Information

ICTRP weblink https://trialsearch.who.int/Trial2.aspx?TrialID=JPRN-UMIN000011929
Other study identifiers
Name UMIN000011929
Description UMIN Clinical Trials Registry (UMIN-CTR)
Source weblink https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000013279
Public contact
Email hirami@fbri.org
First name Yasuhiko
Last name Hirami
Phone 078-302-4321
City Kobe
Address freetext Kobe City Medical Center General Hospital
Sponsors Riken


Which differentiated cell type is used
Label retinal pigment epithelial cell
Link http://purl.obolibrary.org/obo/CL_0002586
Description An epithelial cell of the retinal pigmented epithelium.


Recruitment Status Completed
Comment recruitment status The trial was halted after two patients because of Japan's Regenerative Medicine Law of 2014. (Estimated number of participants was 6).
Estimated number of participants 2