General Information |
Summary |
Phase 1 trial of retinal pigment epithelium replacement in subjects with wet age-related macular degeneration in whom there is rapidly progressing vision loss. |
Description |
Phase 1, open-label, safety and feasibility study of implantation of PF-05206388 (human embryonic stem cell derived retinal pigment epithelium) in subjects with wet age related macular degeneration and rapid vision loss. |
Clinical trials phase |
Phase 1 |
Start date (estimated) |
2021-10-14 |
End date (estimated) |
2024-03-14 |
Clinical feature |
Label |
age related macular degeneration |
Link |
http://purl.obolibrary.org/obo/DOID_10871 |
Description |
A degeneration of macula and posterior pole that is characterized by a loss of vision in the center of the visual field (the macula) resulting from damage to the retina and resulting in blurring of the sharp central vision.; OMIM mapping confirmed by DO. [SN]. |
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Administrative Information |
NCT number |
NCT01691261 |
ICTRP weblink |
https://trialsearch.who.int/Trial2.aspx?TrialID=NCT01691261 |
EudraCT number |
2011-005493-37 |
Other study identifiers |
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Source weblink |
http://www.clinicaltrials.gov/ct2/show/NCT01691261 |
Regulatory body approval |
Name |
Medicines & Healthcare products Regulatory Agency (MHRA) |
Country |
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Study sites |
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Public contact |
Email |
ClinicalTrials.gov_Inquiries@pfizer.com |
Public email |
moorfields.resadmin@nhs.net |
First name |
Tania |
Last name |
West |
Phone |
+44 20725334112036 |
Country |
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Sponsors |
Moorfields Eye Hospital NHS Foundation Trust |
Collaborators |
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Cells |
Source pluripotent stem cell lines |
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Which differentiated cell type is used |
Label |
retinal pigment epithelial cell |
Link |
http://purl.obolibrary.org/obo/CL_0002586 |
Description |
An epithelial cell of the retinal pigmented epithelium. |
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Recruitment |
Recruitment Status |
Recruiting |
Estimated number of participants |
10 |
Contact institutions/departments |
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