A Study of transplantation of allogenic induced pluripotent stem cell (iPSC) derived retinal pigment epithelium (RPE) cell suspension in subjects with neovascular age related macular degeneration

General Information

Description The objectives of this clinical study are to evaluate the safety as well as the feasibility and visual function efficacy of transplantation of RPE cells differentiated from allogenic iPS cells induced from the peripheral blood of 6 HLA locus homozygous donor for HLA haplotype matched subjects with neovascular AMD.
Clinical trials phase Other
Start date (estimated) 2017-02-06
End date (estimated) 2021-09-20
Clinical feature
Label age related macular degeneration
Link http://purl.obolibrary.org/obo/DOID_10871
Description A degeneration of macula and posterior pole that is characterized by a loss of vision in the center of the visual field (the macula) resulting from damage to the retina and resulting in blurring of the sharp central vision.; OMIM mapping confirmed by DO. [SN].

Administrative Information

ICTRP weblink https://trialsearch.who.int/Trial2.aspx?TrialID=JPRN-UMIN000026003
Other study identifiers
Name UMIN000026003
Description UMIN Clinical Trials Registry(UMIN-CTR)
Source weblink https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000029894
Public contact
Email e_kenkyujimu@kcho.jp
Public email e_kenkyujimu@kcho.jp
First name Naoki
Last name Shibatani
City Kobe
Address freetext 2-1-8, Manatojima-minamimachi, Chuo-ku, Kobe Japan 650-0047 Japan
Sponsors Riken
Kobe City Medical Center General Hospital
Osaka University Hospital
Center for iPS Cell Research and Application


Which differentiated cell type is used
Label retinal pigment epithelial cell
Link http://purl.obolibrary.org/obo/CL_0002586
Description An epithelial cell of the retinal pigmented epithelium.


Recruitment Status Completed
Comment recruitment status Follow-up complete
Estimated number of participants 5