A Study of transplantation of allogenic induced pluripotent stem cell (iPSC) derived retinal pigment epithelium (RPE) cell suspension in subjects with neovascular age related macular degeneration

General Information

Description The objectives of this clinical study are to evaluate the safety as well as the feasibility and visual function efficacy of transplantation of RPE cells differentiated from allogenic iPS cells induced from the peripheral blood of 6 HLA locus homozygous donor for HLA haplotype matched subjects with neovascular AMD.
Clinical trials phase Other
Start date (estimated) 2017-02-06
Clinical feature
Label wet macular degeneration
Link http://www.ebi.ac.uk/efo/EFO_0004683
Description A form of RETINAL degeneration in which abnormal CHOROIDAL NEOVASCULARIZATION occurs under the RETINA and MACULA LUTEA, causing bleeding and leaking of fluid. This leads to bulging and or lifting of the macula and the distortion or destruction of central vision.; A form of RETINAL DEGENERATION in which abnormal CHOROIDAL NEOVASCULARIZATION occurs under the RETINA and MACULA LUTEA, causing bleeding and leaking of fluid. This leads to bulging and or lifting of the macula and the distortion or destruction of central vision.

Administrative Information

Other study identifiers
Name UMIN000026003
Description UMIN Clinical Trials Registry(UMIN-CTR)
Source weblink https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000029894
Regulatory body approval
Country
Public contact
Email ts-cr@kcho.jp
Public email ts-cr@kcho.jp
First name Utako
Last name Shirono
Phone +81 (0)78-302-5489
Street 2-1-1, Manatojima-minamimachi, Chuo-ku, Kobe Japan
City Kobe
Country
Sponsors Riken
Kobe City Medical Center General Hospital
Osaka University Hospital
Center for iPS Cell Research and Application

Cell Line

Recruitment

Recruitment Status Completed
Estimated number of participants 5