Clinical trial of human (allogeneic) induced pluripotent stem cell-derived cardiomyocyte sheet for severe cardiomyopathy

General Information

Clinical trials phase Phases 1/2
Start date (estimated) 2019-08-11
End date (estimated) 2022-06-30
Clinical feature
Label cardiomyopathy
Description A heart disease and a myopathy that is characterized by deterioration of the function of the heart muscle.; MESH:D009202 added from NeuroDevNet [WAK].

Administrative Information

ICTRP weblink
Other study identifiers
Name UMIN000032989
Description UMIN Clinical Trials Registry (UMIN-CTR)
Name PA8170002
Source weblink
Public contact
Public email
First name Shigeru
Last name Miyagawa
Phone +81 (0)6-6879-3154
Street 2-2, Yamadaoka, Suita city, Osaka
Postcode 565-0871
City Osaka
Sponsors Osaka University Hospital


Which differentiated cell type is used
Label cardiac muscle cell
Description Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. In mammals, the contractile fiber resembles those of skeletal muscle but are only one third as large in diameter, are richer in sarcoplasm, and contain centrally located instead of peripheral nuclei.; This class encompasses the muscle cells responsible for heart* contraction in both vertebrates and arthropods. The ultrastucture of a wide range of arthropod heart cells has been examined including spiders, horseshoe crabs, crustaceans (see Sherman, 1973 and refs therein) and insects (see Lehmacher et al (2012) and refs therein). According to these refs, the cells participating in heart contraction in all cases are transversely striated. Insects hearts additionally contain ostial cells, also transversely striated muscle cells, but which do not participate in heart contraction.


Recruitment Status Terminated
Estimated number of participants 3