General Information |
| Summary |
Based on the safety evaluation of primates, the best cell transplantation scheme was integrated. One patient with CHF caused by coronary heart disease, one patient with CHF caused by dilatation and one patient with CHF caused by Keshan disease were selected and treated with autologous iPS differentiated cardiomyocyte intravenous transplantation. The safety evaluation of human body was completed and combined with subjective and objective indexes respectively. Structural and functional indicators were used to evaluate the therapeutic effect of cell transplantation. The results of animal experiments confirmed the safety and effectiveness of intravenous myocardial cell transplantation, and clarified its possible mechanism. |
| Clinical trials phase |
Phase 2/3 |
| Start date (estimated) |
2022-12-31 |
| End date (estimated) |
2024-12-31 |
| Clinical feature |
| Label |
heart failure |
| Link |
http://purl.obolibrary.org/obo/SYMP_0000292 |
|
Administrative Information |
| NCT number |
NCT03759405 |
| ICTRP weblink |
https://trialsearch.who.int/Trial2.aspx?TrialID=NCT03759405 |
| Other study identifiers |
|
| Source weblink |
https://clinicaltrials.gov/ct2/show/NCT03759405 |
| Public contact |
| Email |
xuanlong@bucm.edu.cn |
| Public email |
xuanlong@bucm.edu.cn |
| First name |
Anlong |
| Last name |
Xu |
| City |
Beijing |
| Country |
|
|
| Sponsors |
Beijing University of Chinese Medicine
|
Cells |
| Which differentiated cell type is used |
| Label |
cardiac muscle cell |
| Link |
http://purl.obolibrary.org/obo/CL_0000746 |
| Description |
Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. In mammals, the contractile fiber resembles those of skeletal muscle but are only one third as large in diameter, are richer in sarcoplasm, and contain centrally located instead of peripheral nuclei.; This class encompasses the muscle cells responsible for heart* contraction in both vertebrates and arthropods. The ultrastucture of a wide range of arthropod heart cells has been examined including spiders, horseshoe crabs, crustaceans (see Sherman, 1973 and refs therein) and insects (see Lehmacher et al (2012) and refs therein). According to these refs, the cells participating in heart contraction in all cases are transversely striated. Insects hearts additionally contain ostial cells, also transversely striated muscle cells, but which do not participate in heart contraction. |
|
Recruitment |
| Recruitment Status |
Not yet recruiting |
| Estimated number of participants |
3 |
