Safety and Effectiveness of Human embryonic stem cell-derived M cells (CAStem) for Pulmonary Fibrosis Correlated with novel coronavirus pneumonia (COVID-19)

General Information

Clinical trials phase Other
Start date (estimated) 2020-03-20
End date (estimated) 2021-03-19
Clinical feature
Label COVID-19
Description A Coronavirus infectious disease that is characterized by fever, cough and shortness of breath and that has_material_basis_in SARS-CoV-2.

Administrative Information

ICTRP weblink
Other study identifiers
Name ChiCTR2000031139
Description Chinese Clinical Trial Registry (ChiCTR)
Source weblink
Public contact
Public email
First name Liu
Last name Ying
Phone +8627-85509088
City Wuhan
Address freetext 1 Yintan Road, Dongxihu District, Wuhan, Hubei, China
Sponsors Wuhan Jinyintan Hospital (Wuhan Infectious Diseases Hospital)


Which differentiated cell type is used
Label mesenchymal stem cell
Description A connective tissue cell that normally gives rise to other cells that are organized as three-dimensional masses. In humans, this cell type is CD73-positive, CD90-positive, CD105-positive, CD45-negative, CD34-negative, and MHCII-negative. They may further differentiate into osteoblasts, adipocytes, myocytes, neurons, or chondroblasts in vitro. Originally described as residing in the bone marrow, this cell type is now known to reside in many, if not all, adult organs.; Many but not all mesenchymal cells derive from the mesoderm. MSCs are reportedly CD3-negative, CD4-negative, CD5-negative, CD8-negative, CD11a-negative, CD11b-negative, CD14-negative, CD19-negative, CD29-positive, CD31-negative, CD34-negative, CD38-negative, CD40-negative, CD44-positive, CD45-negative, CD49-positive, CD54-positive, CD66b-negative, CD79a-negative, CD80-negative, CD102-positive, CD106-positive, CD117-positive, CD121a-positive, CD121b-positive, CD123-positive, CD124-positive, CD133-negative, CD146-positive, CD166-positive, CD271-positive, B220-negative, Gr1-negative, MHCI-positive, MHCII-negative, SSEA4-negative, sca1-positive, Ter119-negative, and glycophorin A-negative. Cultured MSCs are capable of producing stem cell factor, IL7, IL8, IL11, TGF-beta, cofilin, galectin-1, laminin-receptor 1, cyclophilin A, and MMP-2.


Recruitment Status Recruiting
Estimated number of participants 20
Contact institutions/departments