iPSC-derived platelet transfusion trial1 (iPLAT1)

General Information

Clinical trials phase Phase 1
Start date (estimated) 2019-05-14
Clinical feature
Label aplastic anemia
Link http://purl.obolibrary.org/obo/DOID_12449
Description An anemia that is characterized by a deficiency of red blood cells, white blood cells and platelets produced by bone marrow.; OMIM mapping confirmed by DO. [SN].

Administrative Information

ICTRP weblink https://trialsearch.who.int/Trial2.aspx?TrialID=JPRN-jRCTa050190117
Other study identifiers
Name jRCTa050190117
Description Japan Registry of Clinical Trials (jRCT)
Source weblink https://jrct.niph.go.jp/en-latest-detail/jRCTa050190117
Public contact
Email jkanda16@kuhp.kyoto-u.ac.jp
Public email jkanda16@kuhp.kyoto-u.ac.jp
First name Junya
Last name Kanda
Phone +81-75-751-3150
City Kyoto
Address freetext Kyoto University Hospital, 54 Kawaharacho, Shogoin, Sakyo-ku, Kyoto, Kyoto, Japan
Sponsors Kyoto University Hospital


Which differentiated cell type is used
Label platelet
Link http://purl.obolibrary.org/obo/CL_0000233
Description A non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation.; Platelets are reportedly CCR1-positive, CCR2-negative, CCR3-positive, CCR4-positive, CCR5-negative, CCR6-negative, CCR7-negative, CCR8-negative, CCR9-negative, CCR10-negative, CD16-positive, CD23-positive, CD32-positive, CD40-positive, CD41-positive CD42-positive, CD61-positive, CD62P-positive, CD64-positive, CD89-positive, CD102-positive, CD147-positive (activated platelets), CD154-positive (activated platelets), CD162-positive, CD209, CD282-positive, CD284-positive, CD289-positive, CD181-negative, CD182-negative, CD183-negative, CD184-positive, CLEC2-positive, GPVI-positive, JAMC-positive, PAR1-positive, PAR2-negative, PAR3-positive, PAR4-positive, TSP1-positive, and TXA2R-positive. Platelets can reportedly produce CCL2, CCL3, CCL5, CCL7, CCL17, CD40L, CXCL1, CXCL4, CXCL4L1, CXCL5, CXCL7, CXCL8, CXCL12, EGF, factor V, factor VII, factor XI, factor XIII, bFGF, histamine, IGF-1, IL-1beta, PAI-1, PDGF, plasminogen, protein S, serotonin, TGF-beta, TFPI, VEGF, and vWF.


Recruitment Status Completed
Estimated number of participants 1