Multi-well High-resolution Electrophysiology Platform

Title Multi-well High-resolution Electrophysiology Platform
Acronym MwHresEP
Start date 2017-06-01
End date 2018-05-31
Sponsor European Research Council - Proof of Concept (ERC-PoC)
Institution ETH Zurich

Associated cell lines

Project Description

The aim of this proof-of-concept project is to make initial steps in translating the high-density microelectrode array (HD-MEA) chip technology, which has been developed in the ERC project “NeuroCMOS” (AdG 267351, Subproject 1) into a commercial product. The project will be performed in collaboration with the spin-off company MaxWell Biosystems AG ( that has been founded after the NeuroCMOS project end by collaborators of the PI laboratory and a lab at Riken (Japan) with the purpose to commercialize the developed CMOS-based chip technology and software for neuroscientific research and industrial use in drug discovery and development. The initial steps undertaken in this PoC (Fig. 1) include (i) the development of a multi-well-plate prototype, suitable for drug discovery applications, that can host CMOS microelectrode arrays in each well. Moreover, we will (ii) develop the needed soft- and hardware to prove the feasibility of integrating the chip system prototype into cell-culture automation platforms, and we will work to (iii) obtain initial data from commercially available human induced-pluripotent-stem-cell (iPSC) -derived neurons (Cell line CDli001-A (01279)).