Safeguarding Cell Fate by Terminal Repression during Development and Disease
| Title | Safeguarding Cell Fate by Terminal Repression during Development and Disease |
|---|---|
| Acronym | SafeFate |
| Website | https://www.dkfz.de/en/cell-fate-engineering/index.php |
| Start date | |
| End date | |
| Sponsor | European Research Council - Starting Grant (ERC-StG) |
| Institution | German Cancer Research Center |
Associated cell lines
Project Description
Cell identity and function requires both induction of desired genes and repression of unwanted programs. While master regulators that activate gene networks during development are well characterized, the mechanisms that terminally repress alternative fates remain poorly understood. Within this project, I aim to demonstrate that active terminal repression is a universal mechanism required to prevent loss of cell identity and disease.