A promising Treatment of WWOX Associated Neurological Disorders
|Title||A promising Treatment of WWOX Associated Neurological Disorders|
|Sponsor||Horizon 2020 (H2020)|
|Institution||Hebrew University of Jerusalem|
Associated cell lines
EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 28; EIEE28 or WWOX-related epileptic encephalopathy (WOREE) syndrome is a very severe epileptic encephalopathy characterized by absence of language development and acquisition of walking, early-onset drug-resistant seizures, ophthalmological involvement, and a very high likelihood of premature death. The disease is caused due to an autosomal recessive germline mutation in WW domain-containing oxidoreductase (WWOX) gene. The project aims to generate iPSC lines from EIEE28 patients and their parents [as control] and use them for evaluating treatment purposes.