Dietary shaping of the early life metabolome and its role in healthy lung and brain development - model 2
| Title | Dietary shaping of the early life metabolome and its role in healthy lung and brain development - model 2 |
|---|---|
| Acronym | DEFEND - M2 |
| Website | http://copsac.com/ |
| Start date | 2021-01-01 |
| End date | 2021-06-30 |
| Sponsor | Horizon Europe Framework Programme |
| Institution | Wellcome Sanger Institute |
Associated cell lines
- WTSIi178-A (HPSI0215i-fawm_2)
- WTSIi190-B (HPSI0914i-kajh_2)
- WTSIi294-B (HPSI1014i-bilx_2)
- WTSIi302-A (HPSI1014i-nosn_6)
- WTSIi302-B (HPSI1014i-nosn_1)
- WTSIi446-A (HPSI1113i-vuud_2)
- WTSIi507-A (HPSI0614i-uevq_4)
- WTSIi507-B (HPSI0614i-uevq_6)
Project Description
Human lung organoids (HLO) will be derived from the induced pluripotent stem cells, with 3 different doses of vitamin D and/or n-3 LCPUFA added during derivation to study the effect on the developing HLO model. Outcomes will be assessed with RNAseq, metabolomics, and structural features