Dietary shaping of the early life metabolome and its role in healthy lung and brain development - model 2

Title Dietary shaping of the early life metabolome and its role in healthy lung and brain development - model 2
Acronym DEFEND - M2
Website http://copsac.com/
Start date 2021-01-01
End date 2021-06-30
Sponsor European Research Council (ERC)
Institution Wellcome Trust Sanger Institute

Associated cell lines

Project Description

Human lung organoids (HLO) will be derived from the induced pluripotent stem cells, with 3 different doses of vitamin D and/or n-3 LCPUFA added during derivation to study the effect on the developing HLO model. Outcomes will be assessed with RNAseq, metabolomics, and structural features