Retina Organoid Mechanobiology
| Title | Retina Organoid Mechanobiology |
|---|---|
| Acronym | ROMB |
| Website | https://cordis.europa.eu/project/id/850691/de |
| Start date | 2020-09-01 |
| End date | 2025-08-31 |
| Sponsor | European Research Council - Starting Grant (ERC-StG) |
| Institution | Ludwig-Maximilians-Universität München |
Associated cell lines
Project Description
There is an urgent need for non-invasive Alzheimer’s disease (AD) biomarkers. The retina shares an embryological origin with the brain and may serve as a diagnostic tool reflecting AD hallmark pathology. So far, technological challenges have prevented the establishment of the retina organoid as a biophysical model. The EU-funded ROMB project aims to develop a biophysical model for the retina as an in vitro model of AD. The model will be built using retina organoids as a physiological in vitro model and will allow tissue mechanical measurements and neuronal activity readouts. The researchers propose to model AD using mouse retina organoids with a mutation in the APP gene to study the peptide aggregates that are the hallmark of disease onset.