Retina Organoid Mechanobiology

Title Retina Organoid Mechanobiology
Acronym ROMB
Start date 2020-09-01
End date 2025-08-31
Sponsor European Research Council - Starting Grant (ERC-StG)
Institution Ludwig-Maximilians-Universität München

Associated cell lines

Project Description

There is an urgent need for non-invasive Alzheimer’s disease (AD) biomarkers. The retina shares an embryological origin with the brain and may serve as a diagnostic tool reflecting AD hallmark pathology. So far, technological challenges have prevented the establishment of the retina organoid as a biophysical model. The EU-funded ROMB project aims to develop a biophysical model for the retina as an in vitro model of AD. The model will be built using retina organoids as a physiological in vitro model and will allow tissue mechanical measurements and neuronal activity readouts. The researchers propose to model AD using mouse retina organoids with a mutation in the APP gene to study the peptide aggregates that are the hallmark of disease onset.