Human-ape hybrid iPSCs

Title Human-ape hybrid iPSCs
Acronym HumApeHybs
Start date 2023-01-01
End date
Sponsor European Research Council - Starting Grant (ERC-StG)
Institution Weizmann Institute of Science

Associated cell lines

Project Description

Generation of human-ape hybrid induced pluripotent stem cells (iPSCs) for the study of gene regulatory changes between humans and other apes. This will include human-chimpanzee, human-bonobo, human-gorilla and human-orangutan iPSCs. Hybrid cells will be generated by fusing human and ape iPSCs using PEG, as described in Agoglia et al., Nature 2021 and Gokhman et al., Nature Genetics, 2021. No gametes or embryos will be generated.