Stem cell-derived neural organoids as platforms to investigate glioblastoma invasion and migration: A systematic review

Summary

Human NOs represent promising platforms for modeling glioblastoma invasion in a humanized three-dimensional environment. However, a limited number of studies and methodological heterogeneity hinder reproducibility. Protocol standardization is essential to enhance the translational application of these models. ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.

Authors Alves ADH, Ennes do Valle NM, Yokota-Moreno BY, Galanciak MCDS, Felix da Silva K, Mamani JB, Sertie AL, de Oliveira FA, Nucci MP, Gamarra LF
Journal World journal of stem cells
Publication Date 2025 Aug 26;17(8):108898
PubMed 40951702
PubMed Central PMC12427015
DOI 10.4252/wjsc.v17.i8.108898

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