Generation of two isogenic induced pluripotent stem cell lines derived from a Hispanic individual with Alzheimer's Disease and mosaic for loss of the Y chromosome
Summary
Mosaic loss of the Y chromosome (LOY) is a somatic phenomenon that occurs in males as they age (Jacobs, 1963; Forsberg, 2017; Danielsson, 2020) and is associated with an elevated risk of developing numerous diseases, including Alzheimer's Disease (AD) (Dumanski, 2016; Palmer, et al., 2022; Garcia-Gonzalez, 2023), cancer (Holmes, 1985; Loftfield, 2018), diabetes (Loftfield, 2018), age related macular degeneration (Grassmann, 2019), and autoimmune disease (Persani, 2012; Lleo, 2013). The induced pluripotent cell lines (iPSCs) UMi050-A and UMi050-B were derived from a Hispanic male with loss of the Y chromosome in his blood and diagnosed with AD. This isogenic pair of lines with and without a Y chromosome is a unique resource to delve into the mechanism of LOY and its relationship to AD risk. Copyright © 2025 The Author(s). Published by Elsevier B.V. All rights reserved.
| Authors | Cukier HN, DeRosa BA, Coombs LE, Tang E, Leyva DR, Lazzaro AR, Gu E, Dykxhoorn DM, Haines JL, Pericak-Vance MA, Song YE, Bush WS, Griswold AJ |
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| Journal | Stem cell research |
| Publication Date | 2025 Oct 9;89:103851 |
| PubMed | 41086611 |
| DOI | 10.1016/j.scr.2025.103851 |