Extracellular microRNAs modulate human microglial function through TLR8
Summary
Our data establish that distinct CNS disease-associated miRNAs serve as signaling molecules for human microglia via TLR8, thereby controlling the diverse microglial functions and modulating the neuroinflammatory response. Copyright © 2025 Weidling, Motta, Kuhrt, Krüger, Figueiredo, Wallach, Frahm, Diecke, Wolf, Kettenmann and Lehnardt.
| Authors | Weidling H, Motta E, Kuhrt LD, Krüger C, Figueiredo CA, Wallach T, Frahm S, Diecke S, Wolf SA, Kettenmann H, Lehnardt S |
|---|---|
| Journal | Frontiers in immunology |
| Publication Date | 2025;16:1645062 |
| PubMed | 41322409 |
| PubMed Central | PMC12660282 |
| DOI | 10.3389/fimmu.2025.1645062 |