Generation of iPSC lines from an ADHD patient (UKWi008-A, UKWi008-A-1) and a healthy control (UKWi009-A, UKWi009-A-1)
Summary
Attention-Deficit/Hyperactivity Disorder (ADHD) is a highly heritable neurodevelopmental condition with a complex polygenic architecture and an unclear etiology. Human induced pluripotent stem cells (iPSCs), which retain the donor's genetic background, provide a powerful model to study patient-specific cellular phenotypes in polygenic disorders. We therefore generated iPSCs from an adult with ADHD and a neurotypical control. Both lines exhibit high genomic stability, express key pluripotency-associated markers, and demonstrate trilineage differentiation potential and absence of mycoplasma contamination. These well-characterized iPSC lines provide a valuable resource for investigating ADHD pathophysiology and for identifying novel drug targets to advance therapeutic development. Copyright © 2026 The Author(s). Published by Elsevier B.V. All rights reserved.
| Authors | Schickardt Z, Grüner J, Gücsavas D, Radtke F, Chiocchetti AG, Smigielski L, Yde Ohki CM, Grünblatt E, Üçeyler N, Kittel-Schneider S, McNeill RV |
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| Journal | Stem cell research |
| Publication Date | 2026 Apr;92:103952 |
| PubMed | 41794018 |
| DOI | 10.1016/j.scr.2026.103952 |