Establishment of an induced pluripotent stem cell line from a patient with Leber Congenital Amaurosis
Summary
A human induced pluripotent stem cell (hiPSC) line BTHBIOi006-A was generated from peripheral blood mononuclear cells of a patient carrying RDH12 biallelic mutations via episomal reprogramming. The line exhibits a normal karyotype, expresses pluripotent markers, differentiates into three germ layers, and is mycoplasma-free, serving as a tool for retinal disease research. Copyright © 2026 The Author(s). Published by Elsevier B.V. All rights reserved.
| Authors | Zhang ZH, Zhang XH, Jin ZB |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2026 Apr;92:103933 |
| PubMed | 41759220 |
| DOI | 10.1016/j.scr.2026.103933 |