Tracking tau and cellular responses in human iPSC-microglia: from uptake to seedable secretion, including in extracellular vesicles
Summary
Our study reveals new insights into human microglial responses to tau, highlighting opportunities to limit pathogenic tau spread. © 2026 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
| Authors | Karabova MK, Del Ser-Badia A, Hedegaard A, Washer SJ, Baykam Z, O'Brien DP, Vendrell I, Hester SS, Fischer R, Johnson E, Melia CE, Matthews-Palmer TRS, Matadeen R, Santambrogio A, Metrick MA 2nd, Vendruscolo M, Keeling S, Cheam KAX, McEwan WA, Kosik KS, Day TA, James WS, Cowley SA |
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| Journal | Alzheimer's & dementia : the journal of the Alzheimer's Association |
| Publication Date | 2026 Apr;22(4):e71337 |
| PubMed | 41943483 |
| PubMed Central | PMC13053939 |
| DOI | 10.1002/alz.71337 |