Assessing Aβ-independent effects of Module 42 on immune function in vitro
Summary
We tested M42 proteins for their effects on immune functions in vitro. Five proteins altered phagocytosis, and seven altered Ca2+ signaling. MDK and TMEFF2 ectodomain had an effect on both phagocytosis and Ca2+ signaling. © 2026 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
| Authors | Ajith I, Bakshi S, Mead E, Gileadi O, Katis VL, Brennan PE, Emory‐Sage‐SGC‐Jax TREAT‐AD Center, Gospodinova KO |
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| Journal | Alzheimer's & dementia : the journal of the Alzheimer's Association |
| Publication Date | 2026 Feb;22(2):e71215 |
| PubMed | 41738163 |
| PubMed Central | PMC12933249 |
| DOI | 10.1002/alz.71215 |