Comprehensive assessment of the genomic stability of human induced pluripotent stem cells for clinical applications
Summary
This study established a comprehensive strategy for evaluating the genomic alterations of hiPSCs by integrating karyotyping, OGM, WES, and RNA-seq. This comprehensive strategy can be applied to scenarios such as hiPSC clone screening, establishment of cell bank passages, and quality control of hiPSC-derived products. It provides a reliable genetic stability evaluation protocol to support the safe clinical application of hiPSC-related products. © 2026. The Author(s).
| Authors | Zhang K, Na T, Jia C, Yuan X, Guo M, Yang X, Li M, Jia W, Bai Z, Lu J, Liu Z, Meng S |
|---|---|
| Journal | Stem cell research & therapy |
| Publication Date | 2026 Mar 25;17(1) |
| PubMed | 41877289 |
| PubMed Central | PMC13137665 |
| DOI | 10.1186/s13287-026-04975-w |