Establishment of non-integrate induced pluripotent stem cell line CSUASOi013-A, from peripheral blood-derived cells of a PRPF31-related dominant retinitis pigmentosa patient
Summary
Retinitis pigmentosa (RP) is a common inherited retinal disorder characterized by the progressive degeneration of photoreceptors and retinal pigment epithelial cells. Here, we report the generation of a human induced pluripotent stem cell (iPSC) line, CSUASOi013-A, derived from blood-derived cells of a patient clinically diagnosed with RP carrying a heterozygous duplication of exons 2-13 in the pre-mRNA processing factor 31 (PRPF31) gene (NM_015629.3). The CSUASOi013-A iPSC line exhibits typical pluripotent stem cell morphology, expresses key markers of the undifferentiated state of hPSCs, and retains the disease-associated genetic alteration. This patient-specific iPSC line provides a valuable in vitro resource for studying PRPF31-related RP. Copyright © 2026 The Author(s). Published by Elsevier B.V. All rights reserved.
| Authors | Liang Y, Sun X, Liang Y, Chen H, Duan C, Chen Y, Li W, Gu J, Cui Z, Ding C, Chen J |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2026 May 3;94:104010 |
| PubMed | 42105440 |
| DOI | 10.1016/j.scr.2026.104010 |