Kat5 cKO mouse replicates biological domain signatures associated with Alzheimer's disease

Summary

This analysis supports the hypothesis that KAT5 nuclear signaling downstream of APP cleavage plays a pivotal role in neuronal homeostasis. © 2026 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.

Authors Cary GA, Young JE, Rose SE, Frankowski H, Wilkins H, Amirtha Ganesh SS, Draper J, Darvas M, Bothwell M, Jayadev S, Reid AN, Greenwood A, Levey AI, Leal K, Carter GW, Wiley JC
Journal Alzheimer's & dementia : the journal of the Alzheimer's Association
Publication Date 2026 Jul;22(7):e71562
PubMed 42381348
PubMed Central PMC13319415
DOI 10.1002/alz.71562

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