Rapid generation of human sensory neurons from iPSC for modeling of peripheral neuropathies
Summary
This novel protocol enables rapid generation of human sensory neurons from human iPSCs, achieving 60-70% efficiency. A shorter protocol can improve modeling of small-fiber neuropathies - for example, diabetic peripheral neuropathy and toxic conditions like chemotherapy-induced peripheral neuropathy. Copyright © 2026 Elsevier B.V. All rights reserved.
| Authors | James ME, Chan SSP, Hu B, Farah MH |
|---|---|
| Journal | Journal of neuroscience methods |
| Publication Date | 2026 Oct;434:110837 |
| PubMed | 42336247 |
| PubMed Central | PMC13367118 |
| DOI | 10.1016/j.jneumeth.2026.110837 |