Loss of ABCA4 from photoreceptor discs is associated with glial transcriptomic changes in retinal organoids
Summary
These findings suggest that ABCA4 deficiency in photoreceptor discs may trigger early stress-associated transcriptomic responses in retinal glial cells prior to overt photoreceptor degeneration, potentially contributing to Stargardt disease pathogenesis. © The Author(s) 2026. Published by Oxford University Press.
| Authors | Valenzano R, McDonald A, Gallego C, Andriessen CA, Moustakas I, Mulder AA, Mikkers HMM, Koning RI, Mei H, Wijnholds J |
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| Journal | Stem cells (Dayton, Ohio) |
| Publication Date | 2026 Aug 22;44(9) |
| PubMed | 42581602 |
| PubMed Central | PMC13529370 |
| DOI | 10.1093/stmcls/sxag045 |