Treating Heart Failure With hiPSC-CMs

General Information

Summary Heart failure has a high morbidity and mortality because the heart is one of the least regenerative organs in the human body. Drug treatments for heart failure manage symptoms but do not restore lost myocytes. Cellular replacement therapy is a potential approach to repair damaged myocardial tissue, restore cardiac function, which has become a new strategy for the treatment of heart failure. The purpose of this study is to assess the safety and efficacy of intramyocardial delivery of cardiomyocytes at the time of coronary artery bypass grafting in patients with chronic heart failure.
Description Patients with heart failure will be treated with allogenic human pluripotent stem cell-derived cardiomyocytes ( hPSC-CM ) from healthy donors. The cells will be injected directly into the myocardium at time of coronary artery bypass grafting. Patients will be assessed at 1, 3, 6 and 12 months after cell transplantation for safety and efficacy.
Clinical trials phase Phases 1/2
Start date (estimated) 2022-06-30
End date (estimated) 2025-12-30
Clinical feature
Label heart failure
Link http://purl.obolibrary.org/obo/SYMP_0000292

Administrative Information

NCT number NCT05223894
ICTRP weblink https://trialsearch.who.int/Trial2.aspx?TrialID=NCT05223894
Other study identifiers
Name ZMLiu
Source weblink https://clinicaltrials.gov/ct2/show/NCT05223894
Public contact
Email yanggang@helpsci.com.cn
Public email yanggang@helpsci.com.cn
First name Gang
Phone +86-18601406982
Sponsors Help Therapeutics
Collaborators

Cells

Which differentiated cell type is used
Label cardiac muscle cell
Link http://purl.obolibrary.org/obo/CL_0000746
Description Cardiac muscle cells are striated muscle cells that are responsible for heart contraction. In mammals, the contractile fiber resembles those of skeletal muscle but are only one third as large in diameter, are richer in sarcoplasm, and contain centrally located instead of peripheral nuclei.; This class encompasses the muscle cells responsible for heart* contraction in both vertebrates and arthropods. The ultrastucture of a wide range of arthropod heart cells has been examined including spiders, horseshoe crabs, crustaceans (see Sherman, 1973 and refs therein) and insects (see Lehmacher et al (2012) and refs therein). According to these refs, the cells participating in heart contraction in all cases are transversely striated. Insects hearts additionally contain ostial cells, also transversely striated muscle cells, but which do not participate in heart contraction.

Recruitment

Recruitment Status Recruiting
Estimated number of participants 20