LUMC0111iALK, LUMC0111iALK07

The cell line is not validated yet.

General

Cell Line

hPSCreg name LUMCi017-A
Cite as:
LUMCi017-A (RRID:CVCL_ZA21)
Alternative name(s)
LUMC0111iALK, LUMC0111iALK07
Cell line type Human induced pluripotent stem cell (hiPSC)
Similar lines No similar lines found.
Last update 8th July 2025
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Provider

Generator Leiden University Medical Center (LUMC)
Owner Leiden University Medical Center (LUMC)
Derivation country Netherlands

External Databases

BioSamples SAMEA5966783
Cellosaurus CVCL_ZA21
Wikidata Q98127054

General Information

* Is the cell line readily obtainable for third parties?
No
Subclones

Donor Information

General Donor Information

Sex male
Ethnicity Caucasian

Phenotype and Disease related information (Donor)

Diseases A disease was diagnosed.
The donor is a carrier of a disease-associated mutation and affected.
Synonyms
  • ACVRL1 hereditary hemorrhagic telangiectasia
  • hereditary hemorrhagic telangiectasia caused by mutation in ACVRL1
  • telangiectasia, hereditary hemorrhagic, type 2
  • HHT2
  • ORW2
  • Osler Weber Rendu syndrome type 2
  • hereditary hemorrhagic telangiectasia type 2
  • pulmonary arterial hypertension, hereditary hemorrhagic telangiectasia-related
  • telangiectasia hereditary hemorrhagic type 2
show more synonyms

Karyotyping (Donor)

Has the donor karyotype been analysed?
Yes
KaryoStat™ analysis: no chromosomal aberrations were found when comparing against the reference dataset
Karyotyping method: Array CGH

Other Genotyping (Donor)

Is there genome-wide genotyping or functional data available?
No

External Databases (Donor)

BioSamples SAMEA5966784

Ethics

Has informed consent been obtained from the donor of the embryo/tissue from which the pluripotent stem cells have been derived? Yes
Was the consent voluntarily given? Yes
Has the donor been informed that participation will not directly influence their personal treatment? Yes
Can you provide us with a copy of the Donor Information Sheet provided to the donor? No
Do you (Depositor/Provider) hold the original Donor Consent Form? No
If you do not hold the Donor Consent Form, do you know who does? Yes
Please indicate whether the data associated with the donated material has been pseudonymised or anonymised. pseudonymised
Does consent explicitly allow the derivation of pluripotent stem cells? Yes
* Does consent expressly prevent the derivation of pluripotent stem cells? No
* Does consent pertain to a specific research project? No
Does consent prevent CELLS DERIVED FROM THE DONATED BIOSAMPLE from being made available to researchers anywhere in the world? No
How may genetic information associated with the cell line be accessed? No information
Will the donor expect to receive financial benefit, beyond reasonable expenses, in return for donating the biosample? No
Has a favourable opinion been obtained from a research ethics committee, or other ethics review panel, in relation to the Research Protocol including the consent provisions? Yes
Name of accrediting authority involved? St. Antonius Hospital Nieuwegein
Approval number
Has a favourable opinion been obtained from a research ethics committee, or other ethics review panel, in relation to the PROPOSED PROJECT, involving use of donated embryo/tissue or derived cells? Yes
Name of accrediting authority involved? Leiden University Ethics committee
Approval number P13.080
For generation of the cell line, who was the supplier of any recombined DNA vectors or commercial kits used?

hIPSC Derivation

General

Source cell type
A fibroblast of skin.

Reprogramming method

Vector type Non-integrating
Vector Episomal
Genes
Is reprogramming vector detectable?
No
Methods used
PCR

Vector free reprogramming

Other

Derived under xeno-free conditions
Unknown
Derived under GMP?
Unknown
Available as clinical grade?
Unknown

Culture Conditions

Medium TeSR™ E8™

Characterisation

Analysis of Undifferentiated Cells
Marker Expressed Immunostaining RT-PCR Flow Cytometry Enzymatic Assay Expression Profiles
SSEA-4
Yes
NANOG
Yes
POU5F1 (OCT-4)
Yes
TRA 1-60
Yes
Morphology pictures
Differentiation Potency
Endoderm
Ont Id: UBERON_0000925
Marker Expressed
AFP
Yes
Mesoderm
Ont Id: UBERON_0000926
Marker Expressed
CD31
Yes
Ectoderm
Ont Id: UBERON_0000924
Marker Expressed
B3-tubulin
Yes

Genotyping

Karyotyping (Cell Line)

Has the cell line karyotype been analysed?
Yes
KaryoStat™ analysis: no chromosomal aberrations were found when comparing against the reference dataset
Karyotyping method: Array CGH

Other Genotyping (Cell Line)