General

Cell Line
hPSCreg name	SDQLCHi084-A
Cite as: When citing this cell line, please use the hPSCreg name (see Naming Tool ) and the corresponding Research Resource ID (RRID).	SDQLCHi084-A
Cell line type	Human induced pluripotent stem cell (hiPSC)
Similar lines	No similar lines found.
Last update	16th April 2025
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Provider
Generator	Children’s Hospital affiliated to Shandong University (SDQLCH) Contact: Children's Hospital affiliated to Shandong University (SDQLCH)
External Databases
BioSamples	SAMEA118006143
General Information
* Is the cell line readily obtainable for third parties?	No

Donor Information

General Donor Information
Sex	male
Phenotype and Disease related information (Donor)
Diseases	A disease was diagnosed. Clark-Baraitser syndrome Synonyms Clark-Baraitser syndrome MRD49 intellectual disability, autosomal dominant 49 Baraitser syndrome autosomal dominant intellectual disability 49 autosomal dominant mental retardation 49 intellectual disability, tall stature, obesity, macrocephaly and typical facial features mental retardation, autosomal dominant 49 mental retardation, tall stature, obesity, macrocephaly and typical facial features show more synonyms show less synonyms
Karyotyping (Donor)
Has the donor karyotype been analysed?	Yes 46, XY Karyotyping method: G-Banding
External Databases (Donor)
BioSamples	SAMEA118006145

Ethics

Has informed consent been obtained from the donor of the embryo/tissue from which the pluripotent stem cells have been derived?	Yes
Was the consent voluntarily given?	Yes
Has the donor been informed that participation will not directly influence their personal treatment?	Yes
Can you provide us with a copy of the Donor Information Sheet provided to the donor?	No
Do you (Depositor/Provider) hold the original Donor Consent Form?	Yes
Alternatives to consent are available?	No
Please indicate whether the data associated with the donated material has been pseudonymised or anonymised.	anonymised
Does consent explicitly allow the derivation of pluripotent stem cells?	Yes
Does consent prevent CELLS DERIVED FROM THE DONATED BIOSAMPLE from being made available to researchers anywhere in the world?	Yes
How may genetic information associated with the cell line be accessed?	Open Access
Will the donor expect to receive financial benefit, beyond reasonable expenses, in return for donating the biosample?	No
Has a favourable opinion been obtained from a research ethics committee, or other ethics review panel, in relation to the Research Protocol including the consent provisions?	No
For generation of the cell line, who was the supplier of any recombined DNA vectors or commercial kits used?

hIPSC Derivation

General
Source cell type	Derived Peripheral Blood Mononuclear Cell Mononuclear cells collected from peripheral blood. Synonyms Peripheral Blood Mononuclear cells Derived Peripheral Blood Mononuclear Cell
Reprogramming method
Vector type	Non-integrating
Vector	Episomal
Is reprogramming vector detectable?	No
Methods used	PCR
Vector free reprogramming
Other
Derived under xeno-free conditions	Unknown
Derived under GMP?	Unknown
Available as clinical grade?	Unknown

Culture Conditions

Surface coating	Matrigel/Geltrex
Medium	mTeSR™ Plus

Characterisation

Analysis of Undifferentiated Cells

Marker Expression

Marker	Expressed	Immunostaining	RT-PCR	Flow Cytometry	Enzymatic Assay	Expression Profiles
TRA 1-60	Yes	–
SOX2	Yes	–

EpiPluriScore

Marker	Present	Absent
mCpG
OCT4	X

Morphology

Morphology pictures

Differentiation Potency

Endoderm

Genotyping

Karyotyping (Cell Line)
Has the cell line karyotype been analysed?	Yes 46,XY Passage number: 15
Other Genotyping (Cell Line)