WTSIi018-A-1

Registration Summary:

A P E C

DU545

The cell line is not submitted yet.

(only basic data is shown)

General

Cell Line
hPSCreg name	WTSIi018-A-1
Cite as:	WTSIi018-A-1
Alternative name(s)	DU545
Cell line type	Human induced pluripotent stem cell (hiPSC)
Similar lines	No similar lines found.
Last update	25th March 2026
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Provider
Generator	IUF – Leibniz Research Institute for Environmental Medicine (IUF) Contact: IUF – Leibniz Research Institute for Environmental Medicine (IUF)
Owner	IUF – Leibniz Research Institute for Environmental Medicine (IUF)
Distributors	IUF – Leibniz Research Institute for Environmental Medicine (IUF)
External Databases
BioSamples	SAMEA122018363
General Information
Publications	Evans Lewis D. et al. Whole genome CRISPR screens identify a LRRK2-regulated pathway for extracellular tau uptake by human neurons. . 2020-08-11. Fisch D et al. Toxoplasma-proximal and distal control by GBPs in human macrophages. Pathogens and disease. 2022 Jan 7;79(9). Washer SJ et al. Single-cell transcriptomics defines an improved, validated monoculture protocol for differentiation of human iPSC to microglia. Scientific reports. 2022 Nov 14;12(1):19454. Holden Katie et al. CRISPR/Cas9-mediated knockout of IL1RAPL1 in stem cells highlights a role in neural cell migration during cortical development. . 2022-11-30. Fernandes HJR et al. Mitochondrial and Endoplasmic Reticulum Stress Trigger Triglyceride Accumulation in Models of Parkinson's Disease Independent of Mutations in MAPT. Metabolites. 2023 Jan 9;13(1). Wu Q et al. Massively parallel characterization of CRISPR activator efficacy in human induced pluripotent stem cells and neurons. Molecular cell. 2023 Apr 6;83(7):1125-1139.e8. Vlassis A et al. CRISPR-Cas12a-integrated transgenes in genomic safe harbors retain high expression in human hematopoietic iPSC-derived lineages and primary cells. iScience. 2023 Dec 15;26(12):108287. McMahon E et al. Brazilin is a natural product inhibitor of the NLRP3 inflammasome. iScience. 2024 Feb 16;27(2):108968. Buchner Felix et al. Synchronous 3D patterning of diverse CNS progenitors generates motor neurons of broad axial identity. . 2024-12-17. Rath P et al. Optimizing approaches for targeted integration of transgenic cassettes by integrase-mediated cassette exchange in mouse and human stem cells. Stem cells (Dayton, Ohio). 2025 Jan 17;43(1). Migliori V et al. ONE-STEP tagging: a versatile method for rapid site-specific integration by simultaneous reagent delivery. Nucleic acids research. 2025 Aug 11;53(15). Evans LD et al. Tau uptake by human neurons depends on receptor LRP1 and kinase LRRK2. The EMBO journal. 2025 Sep;44(18):5149-5186. Brezinova M et al. Identification of potent high-affinity secondary nucleation inhibitors of Aβ42 aggregation from an ultra-large chemical library using deep docking. Molecular systems biology. 2026 Jan;22(1):69-87.
* Is the cell line readily obtainable for third parties?	Yes Research use: allowed Clinical use: not allowed Commercial use: not allowed
Subclone of	WTSIi018-A

hIPSC Derivation

General
The source cell information can be found in the parental cell line WTSIi018-A.