XCHIDi001-A

ZZY250101

The cell line is not validated yet.

General

Cell Line

hPSCreg name XCHIDi001-A
Cite as:
XCHIDi001-A
Alternative name(s)
ZZY250101
Cell line type Human induced pluripotent stem cell (hiPSC)
Similar lines No similar lines found.
Last update 25th October 2025
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Provider

Generator Xi'an Children's Hospital (XCHID)

External Databases

BioSamples SAMEA120421956

General Information

* Is the cell line readily obtainable for third parties?
Yes
Research use: allowed
Clinical use: not allowed
Commercial use: allowed

Donor Information

General Donor Information

Sex male

Phenotype and Disease related information (Donor)

Diseases A disease was diagnosed.
Alagille syndrome
The donor is a carrier of a disease-associated mutation and affected.
Synonyms
  • Kartagener syndrome
  • Kartagener's syndrome
  • PCD
  • ciliary motility disorder
  • immotile ciliary syndrome
  • Dextrocardia bronchiectasis and sinusitis
  • Dextrocardia-bronchiectasis-sinusitis syndrome
  • ICS
  • Immotile cilia syndrome, Kartagener type
  • Primary ciliary dyskinesia and situs inversus
  • Primary ciliary dyskinesia, Kartagener type
  • Siewert syndrome
  • bronchiectasis, chronic sinusitis and dextrocardia syndrome
  • ciliary dyskinesia primary
show more synonyms
Disease associated phenotypes
  • biliary obstruction
  • cholestasis
Family history No
Is the medical history available upon request? Yes
Is clinical information available? Yes

Karyotyping (Donor)

Has the donor karyotype been analysed?
Yes
46,XY
Karyotyping method: G-Banding

Other Genotyping (Donor)

Is there genome-wide genotyping or functional data available?
Yes

External Databases (Donor)

BioSamples SAMEA120421957

Ethics

Has informed consent been obtained from the donor of the embryo/tissue from which the pluripotent stem cells have been derived? Yes
Was the consent voluntarily given? Yes
Has the donor been informed that participation will not directly influence their personal treatment? Yes
Can you provide us with a copy of the Donor Information Sheet provided to the donor? No
Do you (Depositor/Provider) hold the original Donor Consent Form? Yes
Please indicate whether the data associated with the donated material has been pseudonymised or anonymised. anonymised
Does consent explicitly allow the derivation of pluripotent stem cells? Yes
* Does consent expressly prevent the derivation of pluripotent stem cells? No
* Does consent pertain to a specific research project? No
Does consent prevent CELLS DERIVED FROM THE DONATED BIOSAMPLE from being made available to researchers anywhere in the world? No

Does consent permit research by

an academic institution? Yes
a public organisation? Yes
a non-profit company? Yes
How may genetic information associated with the cell line be accessed? Controlled Access
Will the donor expect to receive financial benefit, beyond reasonable expenses, in return for donating the biosample? No
Has a favourable opinion been obtained from a research ethics committee, or other ethics review panel, in relation to the Research Protocol including the consent provisions? Yes
Name of accrediting authority involved? the Ethical Committee of the Xi'an Children’s Hospital
Approval number ECXACH-2024A1
For generation of the cell line, who was the supplier of any recombined DNA vectors or commercial kits used?

hIPSC Derivation

General

Source cell type
A peripheral blood cell with a single nucleus. This category includes lymphocytes and monocytes.
Synonyms
  • PERIPHERAL BLOOD MONONUCLEAR CELL
  • Peripheral Blood Mononuclear Cell
  • PBMC

Reprogramming method

Vector type Non-integrating
Vector Sendai virus
Genes
Is reprogramming vector detectable?
No
Methods used
RT-PCR

Vector free reprogramming

Other

Derived under xeno-free conditions
Unknown
Derived under GMP?
Unknown
Available as clinical grade?
Unknown

Culture Conditions

Medium mTeSR™ 1

Characterisation

Analysis of Undifferentiated Cells
Marker Expressed Immunostaining RT-PCR Flow Cytometry Enzymatic Assay Expression Profiles
SOX2
Yes
NANOG
Yes
POU5F1 (OCT-4)
Yes
Morphology pictures
Differentiation Potency
Endoderm
Ont Id: NCIT_C12706
In vitro directed differentiation
Marker Expressed
FOXA2
Yes
FOXA2
Unknown
SOX17
Yes
Mesoderm
Ont Id: UBERON_0000926
In vitro directed differentiation
Marker Expressed
TBX6
Yes
BRACHYURY
Yes
Ectoderm
Ont Id: UBERON_0000924
In vitro directed differentiation
Marker Expressed
PAX6
Unknown
NESTIN
Unknown

Microbiology / Virus Screening

Mycoplasma Negative

Genotyping

Karyotyping (Cell Line)

Has the cell line karyotype been analysed?
Yes
46,XY
Passage number: 18
Karyotyping method: G-Banding

Other Genotyping (Cell Line)