Principles of retinal neuronal lamination from zebrafish to humans

Title Principles of retinal neuronal lamination from zebrafish to humans
Acronym makingtheretina
Website https://www.mpi-cbg.de/research-groups/current-groups/caren-norden/research-focus/
Start date 2018-12-01
End date 2024-12-01
Sponsor European Research Council (ERC)
Institution Max Planck Institute for Molecular Cell Biology and Genetics

Associated cell lines

Project Description

Neuronal lamination is a hallmark of many diverse brain areas where it is important for efficient circuit formation and neuronal wiring. Despite this significance, the cellular and tissue scale principles that ensure successful and robust lamination are not fully understood. In particular, how cell-tissue interactions and biomechanics influence neuronal lamination is only scarcely explored. To fill this gap, we will use the vertebrate retina with its five neuronal cell types arranged in a highly ordered pattern to investigate the emergence of neuronal lamination.