Principles of retinal neuronal lamination from zebrafish to humans
|Title||Principles of retinal neuronal lamination from zebrafish to humans|
|Sponsor||European Research Council (ERC)|
|Institution||Instituto Gulbenkian de Ciência|
Associated cell lines
Neuronal lamination is a hallmark of many diverse brain areas where it is important for efficient circuit formation and neuronal wiring. Despite this significance, the cellular and tissue scale principles that ensure successful and robust lamination are not fully understood. In particular, how cell-tissue interactions and biomechanics influence neuronal lamination is only scarcely explored. To fill this gap, we will use the vertebrate retina with its five neuronal cell types arranged in a highly ordered pattern to investigate the emergence of neuronal lamination.