Synaptic Vulnerability in Ageing and Alzheimer's disease
|Title||Synaptic Vulnerability in Ageing and Alzheimer's disease|
|Sponsor||European Research Council (ERC)|
|Institution||University of Edinburgh|
Associated cell lines
Synapses are essential for cognition, and understanding the vulnerability of synapses to ageing and Alzheimer's disease pathology will be essential for developing therapeutic strategies. In this project, we will examine structure and function of synapses from human stem cell derived neurons. These neurons will be exposed to insults such as Alzheimer's associated pathological proteins to induce synapse dysfunction and loss. Candidate pathways will be manipulated to determine molecular mechanisms involved in synapse degeneration, and candidate therapeutics will be used to determine whether they can prevent or rescue synaptic phenotypes.