Epigenetic regulation of early human development
| Title | Epigenetic regulation of early human development |
|---|---|
| Acronym | ChromaDYN |
| Website | www.elsaesserlab.org |
| Start date | 2024-01-01 |
| End date | 2028-12-31 |
| Sponsor | European Research Council - Consolidator Grant (ERC-CoG) |
| Institution | Karolinska Institutet |
Associated cell lines
Project Description
The proposed project seeks to elucidate the mechanism of PRC2 lineage restriction and totipotency capacitation in the absence of PRC2 activity using genetic and signaling perturbations, single-cell epigenome profiling methodologies and functional screens. The project will yield insights into the role of epigenetic regulators in orchestrating early embryonic development, involve characterization of mutations identified in developmental disorders and provide new strategies to direct early cell fate decisions, e.g. towards in vitro model systems for placental development.