Safeguarding Female Fertility -development of human-relevant in vitro tools for reproductive toxicity
| Title | Safeguarding Female Fertility -development of human-relevant in vitro tools for reproductive toxicity |
|---|---|
| Acronym | SAFER |
| Start date | 2024-04-01 |
| End date | 2029-03-31 |
| Sponsor | European Research Council - Consolidator Grant (ERC-CoG) |
| Institution | Karolinska Institutet |
| Principal investigator | Pauliina Damdimopoulou
E-Mail: pauliina.damdimopoulou@ki.se |
Associated cell lines
Project Description
Chemical health risk assessment has failed to adequately protect women's fertility. Women, along with their oocytes, are exposed to widespread mixtures of human-made chemicals. These chemicals are correlated with accelerated reproductive aging and infertility. Only 0.5% of the chemicals on the market have been well characterized for health risks, and reproductive toxicity in women is typically not covered due to missing tools. SAFER is a project committed to developing novel in vitro tools for female reproductive toxicants. This project will first investigate the impacts of environmental pollution on stem cell-based embryo models, and then utilize this information to develop innovative in vitro assays for chemical screening and prioritization.