Identifying and investigating the role of ribosome heterogeneity in glioblastoma
| Title | Identifying and investigating the role of ribosome heterogeneity in glioblastoma |
|---|---|
| Acronym | RiboHetGB |
| Start date | |
| End date | |
| Sponsor | Horizon 2020 (H2020) |
| Institution | University of Copenhagen |
Associated cell lines
Project Description
Dysregulation of translation can be observed in many cancers. With accumulating evidence for ribosome heterogeneity, a role of the core ribosome itself in translational regulation has been hypothesized. This project aims to investigate ribosome heterogeneity and dysregulation of translation in glioblastoma using patient-derived glioblastoma cell lines. Neural progenitor cells will be cultured and used as a non-pathogenic baseline to normalize the data collected from different glioblastoma cell lines.