The role of ASS1 in mouse embryonic stem cell differentiation into mesendoderm lineages
Summary
ASS1 knockout directs mESCs toward mesendoderm lineage commitment, thereby promoting beating cardiomyocyte generation. Thus, ASS1 acts as a regulatory switch whose absence drives mesendoderm differentiation and enhances cardiomyocyte production. © 2025. The Author(s).
| Authors | Zhao G, Meng Q, Cao S, Jiang Q, Chen Y, Wu B, Li X, Bao S |
|---|---|
| Journal | Stem cell research & therapy |
| Publication Date | 2025 Sep 1;16(1):479 |
| PubMed | 40890876 |
| PubMed Central | PMC12403944 |
| DOI | 10.1186/s13287-025-04622-w |