Familial Alzheimer's disease mutation identifies novel role of SORLA in release of neurotrophic exosomes
Summary
Familial Alzheimer's disease mutation in SORL1 changes interactome of mutant Sortilin-related receptor with A-type repeats (SORLA). Mutant SORLA impairs release of exosomes from neurons and microglia. Mutant exosomes lack neurotrophic qualities. Defect linked to alterations in microRNA content. © 2025 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
| Authors | Juul-Madsen K, Rudolph IM, Gomes JP, Meyer K, Ovesen PL, Gorniak-Walas M, Kokoli M, Telugu NS, von Tangen Sivertsen M, Febbraro F, Sutherland DS, Palmfeldt J, Diecke S, Andersen OM, Selbach M, Willnow TE |
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| Journal | Alzheimer's & dementia : the journal of the Alzheimer's Association |
| Publication Date | 2025 Sep;21(9):e70591 |
| PubMed | 40928027 |
| PubMed Central | PMC12421412 |
| DOI | 10.1002/alz.70591 |