Functional development of photoreceptors in human retinal organoids
Summary
This study defines a comprehensive electrophysiological maturation timeline for photoreceptors in human ROs and establishes D240 as a key benchmark for functional maturity, characterized by peak Ih currents and AP generation capacity equivalent to mature native photoreceptors. These findings provide essential physiological criteria for standardizing RO quality control, enhancing their utility for modeling retinal degenerative diseases and developing cell replacement therapies. © 2026. The Author(s).
| Authors | Zhang Y, Du M, Wang YH, Li M, Jin K, Pan D, Zhang X, Jin ZB |
|---|---|
| Journal | Stem cell research & therapy |
| Publication Date | 2026 Apr 30;17(1) |
| PubMed | 42063112 |
| PubMed Central | PMC13277147 |
| DOI | 10.1186/s13287-026-05027-z |