A human iPSC model with LATS1/2 knockdown (MUSIi012-A-9) for investigating Hippo signaling in stem cell
Summary
This study reports the generation and comprehensive characterization of the LATS1/2 knockdown (KD) induced pluripotent stem cell (iPSC) line, MUSIi012-A-9. Created via CRISPR/Cas9-mediated modification of the LATS2 gene in a parental LATS1-KD line, this resource serves as a crucial human model to investigate the roles of LATS1/2 kinases, key regulators of the Hippo signaling pathway. Comprehensive validation confirmed normal iPSC morphology, pluripotency marker expression (OCT3/4, NANOG, SOX2), genetic stability (46,XX karyotype), and robust multilineage differentiation potential. This well-characterized iPSC line is a vital tool for advancing research into Hippo pathway regulation, lineage specification, and cell fate determination in development and disease. Copyright © 2026 The Authors. Published by Elsevier B.V. All rights reserved.
| Authors | Lorthongpanich C, Srisook P, Jiamvoraphong N, Klaihmon P, Kumsui S, Laowtammathron C, Issaragrisil S |
|---|---|
| Journal | Stem cell research |
| Publication Date | 2026 Jun 29;95:104052 |
| PubMed | 42378908 |
| DOI | 10.1016/j.scr.2026.104052 |