Targeting intermediate mesoderm in induced pluripotent stem cells (iPSCs): identification of novel non coding RNAs driving kidney development and regeneration
| Title | Targeting intermediate mesoderm in induced pluripotent stem cells (iPSCs): identification of novel non coding RNAs driving kidney development and regeneration |
|---|---|
| Acronym | - |
| Website | http://www.ibecbarcelona.eu/iPSCs |
| Start date | 2017-09-16 |
| End date | 2020-09-15 |
| Sponsor | Horizon 2020 (H2020) |
| Institution | Institut de Bioenginyeria de Catalunya (IBEC) |
Associated cell lines
- ESe014-A (ES-4, ES[4])
- ESi031-A (XFiPS-F44-3F-1)
- ESi034-B (CBiPS30-4F-5)
- WAe001-A (H1, WA01)
- WAe009-A (H9, WA09)
Project Description
In this research project we aim to generate human reporter pluripotent stem cell (hPSC) lines for specific renal markers and use them to define efficient renal differentiation protocols in vitro. In order to achieve this goal, we will take advantage of a novel inducible CRISPR/Cas9 platform (iCRISPR) that is currently under development at Montserrat laboratory, namely iCRISPR2 (iC2).