Metastable Epiallele: Role of Epigenetic Variability for the Development of Metabolic and Endocrine Diseases E-Var-Endo

Title	Metastable Epiallele: Role of Epigenetic Variability for the Development of Metabolic and Endocrine Diseases E-Var-Endo
Acronym	E-Var-Edno
Website	https://cordis.europa.eu/project/id/101043991
Start date	2023-02-01
End date	2028-01-31
Sponsor	European Research Council - Consolidator Grant (ERC-CoG)
Institution	Charité - Universitätsmedizin Berlin

Associated cell lines

• HVRDe001-A (HuES1)
• HVRDe003-A (HuES3)
• WAe001-A (H1, WA01)
• WAe009-A (H9, WA09)

Project Description

Obesity is a growing global health crisis, as it is often associated with cardiovascular disease and type 2 diabetes. Epigenetic modifications are emerging as key players in body weight regulation. These chemical marks on DNA regulate gene expression and influence cell function and disease susceptibility. The ERC-funded E-VarEndo project focuses on epigenetic marks established randomly in early embryonic development and shaped by environmental factors in the womb. Researchers will identify such metastable epialleles and unravel how they influence susceptibility to metabolic and endocrine diseases. The E-VarEndo framework extends beyond metabolic conditions, and is expected to help understand epigenetic contributions to a broad range of human diseases, including neurological and cardiovascular conditions.