Alzheimer's disease risk single nucleotide polymorphism rs11218343 is linked to functional expression of SORL1 in microglia
Summary
Our data infer genetically defined expression of SORL1 in microglia as a determinant of protection from pro-inflammatory stimulation, a function likely encoded by a haplotype linked to rs11218343. © 2026 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
| Authors | Gorniak-Walas M, Telugu NS, Rudolph IM, Diecke S, Willnow TE |
|---|---|
| Journal | Alzheimer's & dementia : the journal of the Alzheimer's Association |
| Publication Date | 2026 Apr;22(4):e71390 |
| PubMed | 42002722 |
| PubMed Central | PMC13092420 |
| DOI | 10.1002/alz.71390 |