General

iPSC Line
hPSCreg name	OSRi018-A-1
Cite as: When citing this cell line, please use the hPSCreg name (see Naming Tool ) and the corresponding Research Resource ID (RRID).	OSRi018-A-1
Alternative name(s)	PTS36-SD23
iPSC line type	Human induced pluripotent stem cell (hiPSC)
Similar iPSC lines	OSRi018-A-2 (PTS36-LD3) Donor diseases: Friedreich Ataxia OSRi018-A (PTS36) Donor diseases: Friedreich Ataxia OSRi017-A-1 (PTL6-SD10) Donor diseases: Friedreich Ataxia OSRi017-A-2 (PTL6-LD3) Donor diseases: Friedreich Ataxia UTSWi001-A-1 (FA1ic) Donor diseases: Friedreich Ataxia UTSWi002-A-1 (FA2ic) Donor diseases: Friedreich Ataxia UTSWi003-A-1 (FA3ic) Donor's gene variants: fxn Donor diseases: Friedreich Ataxia UTSWi001-A (FA1) Donor diseases: Friedreich Ataxia UTSWi004-A Donor diseases: Friedreich Ataxia USFi001-A (1CN1.5) Donor diseases: Friedreich Ataxia UTSWi002-A (FA2) Donor diseases: Friedreich Ataxia IGIBi012-A (FA-hiPSC_001) Donor diseases: Friedreich Ataxia IGIBi013-A (FA_hiPSC_002) Donor diseases: Friedreich Ataxia IGIBi016-A (FA-hiPSC_005) Donor diseases: Friedreich Ataxia UTSWi001-A-3 (FA1ic-N) Donor diseases: Friedreich Ataxia UTSWi002-A-2 (FA2-N) Donor diseases: Friedreich Ataxia OSRi017-A (PTL6) Donor diseases: Friedreich Ataxia UTSWi002-A-3 (FA2ic-N) Donor diseases: Friedreich Ataxia UTSWi003-A (FA3) Donor's gene variants: fxn Donor diseases: Friedreich Ataxia UTSWi001-A-2 (FA1-N) Donor diseases: Friedreich Ataxia UTSWi003-A-2 (FA3-N) Donor's gene variants: fxn Donor diseases: Friedreich Ataxia UTSWi003-A-3 (FA3ic-N) Donor's gene variants: fxn Donor diseases: Friedreich Ataxia
Last update	24th October 2025
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Provider
Generator	Ospedale San Raffaele (OSR) Contact: Ospedale San Raffaele (OSR)
Owner	Ospedale San Raffaele (OSR)
Distributors	Ospedale San Raffaele (OSR)
Derivation country	Italy
External iPSC Databases
General iPSC Information
* Is the cell line readily obtainable for third parties?	No
Subclone of	OSRi018-A

iPSC Genetic Modification

Disease/phenotype related modifications

Friedreich Ataxia Synonyms Friedreich's Ataxia Friedreich Ataxia Friedreich ataxia Genetic modifications FXN (target) Type of iPSC Modification Gene knock-out Delivery method CRISPR-associated (CRISPR/Cas) System

Donor Information

General Donor Information
Sex	male
Ethnicity	Caucasic
Phenotype and Disease related information (Donor)
Diseases	A disease was diagnosed. Friedreich Ataxia Synonyms Friedreich's Ataxia Friedreich Ataxia Friedreich ataxia

Ethics

Also have a look at the ethics information for the parental line OSRi018-A .

For generation of the cell line, who was the supplier of any recombined DNA vectors or commercial kits used?

iPSC Derivation

General
The source cell information can be found in the parental cell line OSRi018-A.
Reprogramming method
Vector free reprogramming
Other
Derived under xeno-free conditions	Unknown
Derived under GMP?	Unknown
Available as clinical grade?	Unknown

iPSC Culture Conditions

Surface coating	Matrigel/Geltrex
Feeder cells	No
Passage method	Enzymatically Accutase
O2 Concentration	20 %
CO2 Concentration	5 %
Medium	mTeSR™ 1
Has Rock inhibitor (Y27632) been used at passage previously with this iPSC line?	Yes
Has Rock inhibitor (Y27632) been used at cryo previously with this iPSC line?	Yes
Has Rock inhibitor (Y27632) been used at thaw previously with this iPSC line?	Yes

iPSC Characterisation

No characterisation data could be found for this subclone. Please open parental cell line OSRi018-A .

Genotyping

Karyotyping (iPSC Line)

Other Genotyping (iPSC Line)