XLC-348

The cell line is not validated yet.

General

Cell Line

hPSCreg name CBi001-A
Cite as:
CBi001-A (RRID:CVCL_IT53)
Alternative name(s)
XLC-348
Cell line type Human induced pluripotent stem cell (hiPSC)
Similar lines
CBi002-A
(XLC303, CSC-C00122)
Donor diseases:
obsolete_schizophrenia
VUi005-A
(787.3)
Donor diseases:
Schizophrenia
VUi006-A
(SCZ 21.5)
Donor diseases:
Schizophrenia
VUi008-A
(SCZ 6.2)
Donor diseases:
Schizophrenia
VUi024-A
(SCZ 9.4)
Donor diseases:
Schizophrenia
VUi009-A
(SCZ 10.1)
Donor diseases:
Schizophrenia
VUi010-A
(SCZ 1.1)
Donor diseases:
Schizophrenia
VUi012-A
(SCZ 7.2)
Donor diseases:
Schizophrenia
VUi013-A
(804.3)
Donor diseases:
Schizophrenia
VUi017-A
(SCZ4.3)
Donor diseases:
Schizophrenia
Last update 22nd August 2022
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Provider

Generator Creative Bioarray (CB)
Distributors
Derivation country United States

External Databases

BioSamples SAMEA4458267
Cellosaurus CVCL_IT53
Wikidata Q54994835

General Information

Projects
* Is the cell line readily obtainable for third parties?
Yes
Research use: allowed
Clinical use: allowed
Commercial use: allowed

Donor Information

General Donor Information

Sex male
Age of donor (at collection) 20-24
Ethnicity Caucasian, Jewish

Phenotype and Disease related information (Donor)

Diseases A disease was diagnosed.
The donor is affected.
Synonyms
  • Other specified types of schizophrenia, unspecified state
  • SCHIZOPHRENIA NEC-UNSPEC
  • Schizophrenia (disorder)
  • SCHIZO NEC-CHR/EXACERB
  • Unspecified schizophrenia (disorder)
  • Disorder, Schizophrenic
  • Other specified types of schizophrenia, chronic state
  • SCHIZO NEC-SUBCHR/EXACER
  • Schizophrenia, NOS
  • [X]Schizophrenia, unspecified
  • Unspecified schizophrenia, chronic state with acute exacerbation
  • schizophrenia-1
  • Unspecified schizophrenia, subchronic state with acute exacerbation
  • Schizophrenic Disorder
  • Schizophrenia NOS (disorder)
  • Schizophrenic Disorders
  • Other specified types of schizophrenia, subchronic state with acute exacerbation
  • Schizophrenia NOS
  • Dementia Praecox
  • SCHIZO NOS-CHR/EXACERB
  • Other specified types of schizophrenia, subchronic state
  • Unspecified schizophrenia, unspecified state
  • Other specified types of schizophrenia
  • Schizophrenic disorders (disorder)
  • Other specified types of schizophrenia, in remission
  • SCHIZOPHRENIA NEC-SUBCHR
  • SCHIZOPHRENIA NEC-CHR
  • SCHIZOPHRENIC DIS
  • Schizophrenias
  • [X]Schizophrenia, unspecified (disorder)
  • Unspecified schizophrenia
  • SCHIZOPHRENIA NEC-REMISS
  • SCHIZOPHRENIA NOS-UNSPEC
  • Disorders, Schizophrenic
  • SCHIZO NOS-SUBCHR/EXACER
  • Other specified types of schizophrenia, chronic state with acute exacerbation
  • SCZ
show more synonyms
Disease associated phenotypes
  • paralogical thinking
  • affective shielding
  • splitting of affect from content
  • suspiciousness
Family history positive family history
Is the medical history available upon request? no
Is clinical information available? no

Karyotyping (Donor)

Has the donor karyotype been analysed?
Yes
47,XY,+mar[1]/46,XY[24]

External Databases (Donor)

BioSamples SAMEA4458266

Ethics

Has informed consent been obtained from the donor of the embryo/tissue from which the pluripotent stem cells have been derived? Yes
Was the consent voluntarily given? Yes
Has the donor been informed that participation will not directly influence their personal treatment? Yes
Can you provide us with a copy of the Donor Information Sheet provided to the donor? No
Please provide contact information of the holder of the original Donor Information Sheet.
Do you (Depositor/Provider) hold the original Donor Consent Form? No
If you do not hold the Donor Consent Form, do you know who does? Yes
Please provide the contact information
Has the donor agreed to be re-contacted? No
Has the donor been informed about how her/his data will be protected? No
Please indicate whether the data associated with the donated material has been pseudonymised or anonymised. pseudonymised
Does consent explicitly allow the derivation of pluripotent stem cells? No
Does consent expressly prevent the derivation of pluripotent stem cells? Yes
Does consent pertain to a specific research project? No
Does consent permit unforeseen future research, without further consent? No
Does the consent permit uses of donated embryo/tissue or derived cell line intended for clinical treatment or human applications? No
Does consent expressly prevent development of commercial products? No
Does consent expressly prevent financial gain from any use of the donated embryo/tissue, including any product made from it? No
Does consent expressly permit storage of donated embryo/tissue for an unlimited time? No
Does consent prevent the DONATED BIOSAMPLE from being made available to researchers anywhere in the world? Yes
Does consent prevent CELLS DERIVED FROM THE DONATED BIOSAMPLE from being made available to researchers anywhere in the world? Yes

Does consent permit research by

an academic institution? Yes
a public organisation? Yes
a non-profit company? Yes
a for-profit corporation? No
How may genetic information associated with the cell line be accessed?
Will the donor expect to receive financial benefit, beyond reasonable expenses, in return for donating the biosample? No
Are you aware of any further constraints on the use of the donated embryo/tissue or derived cells? No
For generation of the cell line, who was the supplier of any recombined DNA vectors or commercial kits used?

hIPSC Derivation

General

Source cell type
A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped.; These cells may be vimentin-positive, fibronectin-positive, fsp1-positive, MMP-1-positive, collagen I-positive, collagen III-positive, and alpha-SMA-negative.
Age of donor (at collection) 20-24

Reprogramming method

Vector type Integrating

Vector free reprogramming

Other

Derived under xeno-free conditions
No
Derived under GMP?
No
Available as clinical grade?
No

Culture Conditions

Medium Other medium:
Base medium: DMEM/F12
Main protein source: Knock-out serum replacement
Serum concentration: %

Characterisation

Analysis of Undifferentiated Cells
Marker Expressed Immunostaining RT-PCR Flow Cytometry Enzymatic Assay Expression Profiles
NANOG
Yes
SOX2
Yes
POU5F1 (OCT-4)
Yes
DNMT3B
Yes
TERT
Yes
Differentiation Potency
Endoderm
Ont Id: UBERON_0000925
In vitro spontaneous differentiation
Mesoderm
Ont Id: UBERON_0000926
In vitro spontaneous differentiation
Ectoderm
Ont Id: UBERON_0000924
In vitro spontaneous differentiation
In vitro directed differentiation

Genotyping

Karyotyping (Cell Line)

Has the cell line karyotype been analysed?
Yes
47,XY,+mar[1]/46,XY[24]

Other Genotyping (Cell Line)