SCZ 7.2

General

Cell Line

hPSCreg name VUi012-A
Cite as:
VUi012-A (RRID:CVCL_ZB13)
Alternative name(s)
SCZ 7.2
Cell line type Human induced pluripotent stem cell (hiPSC)
Similar lines
VUi005-A
(787.3)
Donor diseases:
Schizophrenia
VUi006-A
(SCZ 21.5)
Donor diseases:
Schizophrenia
VUi008-A
(SCZ 6.2)
Donor diseases:
Schizophrenia
VUi009-A
(SCZ 10.1)
Donor diseases:
Schizophrenia
VUi010-A
(SCZ 1.1)
Donor diseases:
Schizophrenia
VUi013-A
(804.3)
Donor diseases:
Schizophrenia
VUi017-A
(SCZ4.3)
Donor diseases:
Schizophrenia
VUi024-A
(SCZ 9.4)
Donor diseases:
Schizophrenia
VUi011-A
(SCZ 3.5)
Donor diseases:
Schizophrenia
MLUi001-M
Donor diseases:
Schizophrenia
MLUi002-G
Donor diseases:
Schizophrenia
NMIi002-A
Donor diseases:
Schizophrenia
NMIi005-A
Donor diseases:
Schizophrenia
NMIi002-B
Donor diseases:
Schizophrenia
MHRCCGi001-A
(P1SH)
Donor diseases:
Schizophrenia
SZGJMSi001-A
(ZLP-2)
Donor diseases:
Schizophrenia
NMIi004-A
Donor diseases:
Schizophrenia
NMIi006-A
Donor diseases:
Schizophrenia
NMIi006-B
Donor diseases:
Schizophrenia
WCHi006-A
Donor diseases:
Schizophrenia
WCHi003-A
Donor diseases:
Schizophrenia
UJSi001-A
Donor diseases:
Schizophrenia
UMILi012-A
(WVS02)
Donor diseases:
Weaver Syndrome
UMILi014-A
(WVS04)
Donor diseases:
Weaver Syndrome
UMILi020-A
(WBS04)
Donor diseases:
Williams-Beuren syndrome
UMILi022-A
(WBS01)
Donor diseases:
Williams-Beuren syndrome
UMGWi001-B
(Z1 K3v3)
Donor diseases:
Floating-Harbor syndrome
STBCi110-A
(SFC116-03-01)
Donor's gene variants:
CFH
Donor diseases:
type 2 diabetes mellitus
age-related macular degeneration
WTSIi167-A
(HPSI1013i-funy_1)
Donor diseases:
Bardet-Biedl syndrome
WTSIi414-B
(HPSI0614i-eisk_6)
Donor diseases:
Bardet-Biedl syndrome
WTSIi405-B
(HPSI0614i-fovu_5)
Donor diseases:
Bardet-Biedl syndrome
WTSIi458-B
(HPSI0614i-lipl_5)
Donor diseases:
Bardet-Biedl syndrome
WTSIi573-A
(HPSI0115i-qaqp_4)
Donor diseases:
Bardet-Biedl syndrome
WTSIi447-A
(HPSI0416i-zige_5)
Donor diseases:
Usher syndrome
WTSIi576-A
(HPSI0216i-feht_1)
Donor diseases:
Usher syndrome
WTSIi450-A
(HPSI0216i-aiid_1)
Donor diseases:
Usher syndrome
WTSIi452-A
(HPSI0115i-xaka_2)
Donor diseases:
Bardet-Biedl syndrome
WTSIi454-A
(HPSI0516i-iool_6)
Donor diseases:
Usher syndrome
WTSIi402-B
(HPSI0714i-ouzk_4)
Donor diseases:
Bardet-Biedl syndrome
WTSIi465-B
(HPSI0714i-xiry_1)
Donor diseases:
Bardet-Biedl syndrome
WTSIi458-A
(HPSI0614i-lipl_2)
Donor diseases:
Bardet-Biedl syndrome
WTSIi465-A
(HPSI0714i-xiry_5)
Donor diseases:
Bardet-Biedl syndrome
WTSIi407-B
(HPSI0914i-hidy_3)
Donor diseases:
Bardet-Biedl syndrome
WTSIi478-A
(HPSI0414i-nolz_4)
Donor diseases:
Bardet-Biedl syndrome
WTSIi614-A
(HPSI0616i-rily_3)
Donor diseases:
Spastic paraplegia
WTSIi452-B
(HPSI0115i-xaka_1)
Donor diseases:
Bardet-Biedl syndrome
WTSIi487-A
(HPSI0516i-goek_4)
Donor diseases:
Usher syndrome
WTSIi573-B
(HPSI0115i-qaqp_5)
Donor diseases:
Bardet-Biedl syndrome
WTSIi450-B
(HPSI0216i-aiid_6)
Donor diseases:
Usher syndrome
WTSIi516-B
(HPSI0216i-iogu_6)
Donor diseases:
Usher syndrome
Last update 6th October 2023
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Provider

Generator Vrije Universiteit Amsterdam (VU)

External Databases

Cellosaurus CVCL_ZB13
Wikidata Q98134636
BioSamples SAMEA114469022

General Information

* Is the cell line readily obtainable for third parties?
No

Donor Information

General Donor Information

Sex male

Phenotype and Disease related information (Donor)

Diseases A disease was diagnosed.
Synonyms
  • Schizophrenia
  • schizophrenia
  • Schizophrenia, unspecified

External Databases (Donor)

BioSamples SAMEA114469023

Ethics

Has informed consent been obtained from the donor of the embryo/tissue from which the pluripotent stem cells have been derived? Yes
Was the consent voluntarily given? Yes
Has the donor been informed that participation will not directly influence their personal treatment? Yes
Can you provide us with a copy of the Donor Information Sheet provided to the donor? Yes
Do you (Depositor/Provider) hold the original Donor Consent Form? No
If you do not hold the Donor Consent Form, do you know who does? Yes
Please provide the contact information anna.kahler@ki.se
Alternatives to consent are available? Yes
Alternatives to consent original swedish instead of english
Alternative consent approval number
Please indicate whether the data associated with the donated material has been pseudonymised or anonymised. pseudonymised
Does consent explicitly allow the derivation of pluripotent stem cells? Yes
Does consent prevent CELLS DERIVED FROM THE DONATED BIOSAMPLE from being made available to researchers anywhere in the world? Yes
How may genetic information associated with the cell line be accessed? Controlled Access
Will the donor expect to receive financial benefit, beyond reasonable expenses, in return for donating the biosample? No
Has a favourable opinion been obtained from a research ethics committee, or other ethics review panel, in relation to the Research Protocol including the consent provisions? Yes
Name of accrediting authority involved? Swedish Ethical Review Authority
Approval number 2011-324-31 and 2012/214-32
Has a favourable opinion been obtained from a research ethics committee, or other ethics review panel, in relation to the PROPOSED PROJECT, involving use of donated embryo/tissue or derived cells? Yes
Name of accrediting authority involved? Swedish Ethical Review Authority
Approval number 2011-324-31 and 2012/214-32
For generation of the cell line, who was the supplier of any recombined DNA vectors or commercial kits used?

hIPSC Derivation

General

Source cell type
A connective-tissue cell of mesenchymal origin that secretes proteins and especially molecular collagen from which the extracellular fibrillar matrix of connective tissue forms.

Reprogramming method

Vector type Non-integrating
Vector Episomal

Vector free reprogramming

Other

Derived under xeno-free conditions
Unknown
Derived under GMP?
Unknown
Available as clinical grade?
Unknown

Culture Conditions

Surface coating Vitronectin
Feeder cells
No
Passage method Enzyme-free cell dissociation
Gentle Cell Dissociation Reagent
O2 Concentration 5 %
Medium TeSR™ E8™
Supplements
PenStrep 0.5 %

Characterisation

Analysis of Undifferentiated Cells
Marker Expressed Immunostaining RT-PCR Flow Cytometry Enzymatic Assay Expression Profiles
POU5F1 (OCT-4)
Yes
SSEA-4
Yes
Morphology pictures
Differentiation Potency
Endoderm
Ont Id: UBERON_0000925
In vitro spontaneous differentiation
Morphology
Mesoderm
Ont Id: UBERON_0000926
In vitro spontaneous differentiation
Morphology
Ectoderm
Ont Id: UBERON_0000924
Morphology

Genotyping

Karyotyping (Cell Line)

Has the cell line karyotype been analysed?
No

Other Genotyping (Cell Line)