PPMI_3469, FCDI_11468

General

Cell Line

hPSCreg name CDIi077-A
Cite as:
CDIi077-A (RRID:CVCL_D5NV)
Alternative name(s)
PPMI_3469, FCDI_11468
Cell line type Human induced pluripotent stem cell (hiPSC)
Similar lines
LCSBi012-A-1
(RHOT1_T610A_clone62.19.37_IsogenicControl)
Donor diseases:
Parkinson Disease
LCSBi008-A-1
(delP GC13, DJ-1-delP GC13)
Donor diseases:
Parkinson Disease
SUSMi005-A-1
(SNCA3X 0KO C1, SNCA3X 0KO C2)
Donor diseases:
obsolete_Parkinson's disease
SUSMi005-A-2
(SNCA3X 1KO C2, SNCA3X 1KO C1)
Donor diseases:
obsolete_Parkinson's disease
SUSMi005-A-3
(SNCA3X 2KO C1, SNCA3X 2KO C2)
Donor diseases:
obsolete_Parkinson's disease
SUSMi005-A-4
(SNCA3X 3KO C1, SNCA3X 3KO C2)
Donor diseases:
obsolete_Parkinson's disease
SUSMi005-A-5
(SNCA3X 4KO C1, SNCA3X 4KO C2)
Donor diseases:
obsolete_Parkinson's disease
LCSBi011-A-1
(RHOT1_T351A_clone25.2_IsogenicControl)
Donor diseases:
Parkinson Disease
EDi001-A-1
(AST22-C, AST23-C)
Donor's gene variants:
SNCA, SNCA
Donor diseases:
Parkinson disease
EDi001-A-2
(AST23-1KO-3, AST22-1KO-3, AST-23_SCAKO Clone 3, AST-22_SNCAKO Clone 3)
Donor's gene variants:
SNCA, SNCA, SNCA, SNCA
Donor diseases:
Parkinson disease
EDi001-A-3
(AST23_SNCAKO Clone 1, AST22-1KO-1, AST23-1KO-1, AST22_SNCAKO Clone 1)
Donor's gene variants:
SNCA, SNCA, SNCA, SNCA
Donor diseases:
Parkinson disease
EDi001-A-4
(AST22-2KO-6, AST23_SNCAKO Clone 6, AST22_SNCAKO Clone 6, AST23-2KO-6)
Donor's gene variants:
SNCA, SNCA, SNCA, SNCA
Donor diseases:
Parkinson disease
MPIi003-A-1
(IM2GC, L2-2GC)
Donor diseases:
obsolete_Parkinson's disease
EDi001-B-1
(AST18-7A)
Donor's gene variants:
SNCA
Donor diseases:
Parkinson disease
EDi001-B-2
(AST18-7B)
Donor's gene variants:
SNCA
Donor diseases:
Parkinson disease
EDi001-B-3
(AST18-5D)
Donor's gene variants:
SNCA
Donor diseases:
Parkinson disease
EDi001-B-4
(AST18-6A)
Donor's gene variants:
SNCA
Donor diseases:
Parkinson disease
EDi001-A-5
(AST23-2KO-II8B)
Donor's gene variants:
SNCA
Donor diseases:
Parkinson disease
CDIi013-A
(PPMI_3409, FCDI_11287)
Donor diseases:
Parkinson Disease
CDIi014-A
(FCDI_11292, PPMI_4055)
Donor diseases:
Parkinson Disease
CDIi017-A
(PPMI_3446, FCDI_11296)
Donor diseases:
Parkinson Disease
CDIi018-A
(PPMI_3234, FCDI_11298)
Donor diseases:
Parkinson Disease
CDIi019-A
(PPMI_52062, FCDI_11299)
Donor diseases:
Parkinson Disease
CDIi021-A
(PPMI_3459, FCDI_11301)
Donor diseases:
Parkinson Disease
CDIi023-A
(FCDI_11303, PPMI_3448)
Donor diseases:
Parkinson Disease
CDIi025-A
(FCDI_11306, PPMI_40273)
Donor diseases:
Parkinson Disease
CDIi029-A
(PPMI_3665, FCDI_11310)
Donor diseases:
Parkinson Disease
CDIi031-A
(PPMI_3451, FCDI_11312)
Donor diseases:
Parkinson Disease
CDIi034-A
(PPMI_51440, FCDI_11317)
Donor diseases:
Parkinson Disease
CDIi037-A
(PPMI_52530, FCDI_11321)
Donor diseases:
Parkinson Disease
CDIi039-A
(FCDI_11325, PPMI_56761)
Donor diseases:
Parkinson Disease
CDIi041-A
(FCDI_11328, PPMI_56435)
Donor diseases:
Parkinson Disease
CDIi042-A
(PPMI_41486, FCDI_11329)
Donor diseases:
Parkinson Disease
CDIi047-A
(FCDI_11341, PPMI_3471)
Donor diseases:
Parkinson Disease
CDIi050-A
(PPMI_4098, FCDI_11344)
Donor diseases:
Parkinson Disease
CDIi053-A
(PPMI_3422, FCDI_11347)
Donor diseases:
Parkinson Disease
CDIi056-A
(PPMI_51971, FCDI_11353)
Donor diseases:
Parkinson Disease
CDIi060-A
(FCDI_11370, PPMI_55251)
Donor diseases:
Parkinson Disease
CDIi064-A
(PPMI_3475, FCDI_11438)
Donor diseases:
Parkinson Disease
CDIi066-A
(FCDI_11446, PPMI_4111)
Donor diseases:
Parkinson Disease
CDIi067-A
(FCDI_11447, PPMI_3960)
Donor diseases:
Parkinson Disease
CDIi069-A
(PPMI_3666, FCDI_11449)
Donor diseases:
Parkinson Disease
CDIi071-A
(PPMI_4108, FCDI_11455)
Donor diseases:
Parkinson Disease
CDIi078-A
(FCDI_11469, PPMI_3467)
Donor diseases:
Parkinson Disease
CDIi087-A
(PPMI_4106, FCDI_11491)
Donor diseases:
Parkinson Disease
CDIi088-A
(PPMI_4107, FCDI_11492)
Donor diseases:
Parkinson Disease
CDIi089-A
(FCDI_11493, PPMI_4109)
Donor diseases:
Parkinson Disease
CDIi090-A
(FCDI_11494, PPMI_4110)
Donor diseases:
Parkinson Disease
CDIi093-A
(PPMI_3953, FCDI_11505)
Donor diseases:
Parkinson Disease
CDIi095-A
(FCDI_11512, PPMI_53988)
Donor diseases:
Parkinson Disease
Last update 17th April 2024
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Provider

Generator FUJIFILM Cellular Dynamics, Inc. (CDI)
Owner The Michael J. Fox Foundation (MJFF)
Distributors
Derivation country United States

External Databases

BioSamples SAMEA115473888
Cellosaurus CVCL_D5NV

General Information

Publications
* Is the cell line readily obtainable for third parties?
Yes
Research use: allowed
Clinical use: not allowed
Commercial use: not allowed

Donor Information

General Donor Information

Sex male
Age of donor (at collection) 60-64

Phenotype and Disease related information (Donor)

Diseases A disease was diagnosed.
Synonyms
  • Parkinson Disease
  • Parkinson's disease
  • Parkinson's Disease

External Databases (Donor)

BioSamples SAMEA115473889

Ethics

Has informed consent been obtained from the donor of the embryo/tissue from which the pluripotent stem cells have been derived? Yes
Was the consent voluntarily given? Yes
Has the donor been informed that participation will not directly influence their personal treatment? Yes
Can you provide us with a copy of the Donor Information Sheet provided to the donor? No
Provide contact information of the holder of the original Donor Information Sheet: ppmi@michaeljfox.org
Do you (Depositor/Provider) hold the original Donor Consent Form? No
If you do not hold the Donor Consent Form, do you know who does? Yes
Contact information / weblink ppmi@michaeljfox.org
Please indicate whether the data associated with the donated material has been pseudonymised or anonymised. pseudonymised
Does consent explicitly allow the derivation of pluripotent stem cells? Yes
Does consent prevent CELLS DERIVED FROM THE DONATED BIOSAMPLE from being made available to researchers anywhere in the world? No
How may genetic information associated with the cell line be accessed? Controlled Access
Will the donor expect to receive financial benefit, beyond reasonable expenses, in return for donating the biosample? No
Has a favourable opinion been obtained from a research ethics committee, or other ethics review panel, in relation to the Research Protocol including the consent provisions? Yes
Name of accrediting authority involved? PPMI
Approval number 001
Has a favourable opinion been obtained from a research ethics committee, or other ethics review panel, in relation to the PROPOSED PROJECT, involving use of donated embryo/tissue or derived cells? Yes
Name of accrediting authority involved? PPMI
Approval number 001
Is there an MTA available for the cell line? No

hIPSC Derivation

General

Source cell type
A cell found predominately in the blood.
Age of donor (at collection) 60-64

Reprogramming method

Vector type Non-integrating
Vector Episomal
Is reprogramming vector detectable?
No

Vector free reprogramming

Other

Derived under xeno-free conditions
Unknown
Derived under GMP?
Unknown
Available as clinical grade?
Unknown

Culture Conditions

Medium Essential 8™

Characterisation

Analysis of Undifferentiated Cells
Marker Expressed Immunostaining RT-PCR Flow Cytometry Enzymatic Assay Expression Profiles
POU5F1 (OCT-4)
Yes
NANOG
Yes
LIN28
Yes
Undifferentiated cells were analyzed by proprietary assays approved by California Institute of Regenerative Medicine (CIRM) as described in the attached publication. Pluripotency of established iPSC cultures were tested by qPCR on bulk samples using 48 genes including standard pluripotency genes (listed above). Samples were assigned a passing score after analysis with a non-supervised classifier based on an appropriate sample set. (Novak, T. 2015. Drug Discovery World pp. 47-53.)
Differentiation Potency
Endoderm
Ont Id: UBERON_0000925
Mesoderm
Ont Id: UBERON_0000926
Ectoderm
Ont Id: UBERON_0000924

Microbiology / Virus Screening

HIV 1 Negative
HIV 2 Negative
Hepatitis B Negative
Hepatitis C Negative
Mycoplasma Negative

Genotyping

Karyotyping (Cell Line)

Has the cell line karyotype been analysed?
Yes
Normal

Other Genotyping (Cell Line)