IBTCMi003-A

AD1

General

Cell Line

hPSCreg Name
IBTCMi003-A
Alternative name(s)
AD1
Cell line type Human induced pluripotent stem cell (hiPSC)
Similar lines
UMi042-A-1
(408737 CB9)
Donor diseases:
Alzheimer's Disease
STBCi006-A-1
(ApoE KO)
Donor's gene variants:
APOE, APOE
Donor diseases:
Alzheimer disease
STBCi006-A-3
(ApoE 3/3)
Donor's gene variants:
APOE, APOE
Donor diseases:
Alzheimer disease
STBCi006-A-4
(ApoE 3/4)
Donor's gene variants:
APOE, APOE
Donor diseases:
Alzheimer disease
UKBi011-A-1
(iLB-AD + ApoE KO)
Donor's gene variants:
APOE, APOE
Donor diseases:
Alzheimer disease
UKBi011-A-2
(ApoE 2/2)
Donor's gene variants:
APOE, APOE
Donor diseases:
Alzheimer disease
UKBi011-A-3
(ApoE 3/3)
Donor's gene variants:
APOE, APOE
Donor diseases:
Alzheimer disease
UKBi011-A-4
(ApoE 3/4)
Donor's gene variants:
APOE, APOE
Donor diseases:
Alzheimer disease
IBTCMi004-A
(AD2)
Donor diseases:
Alzheimer's Disease
IBTCMi005-A
(AD3)
Donor diseases:
Alzheimer's Disease
SIAISi006-A
(JJY)
Donor diseases:
Alzheimer's Disease
ZZUi010-A
(ZZU-iPS-AD-APP-001)
Donor diseases:
obsolete_Alzheimer's disease
MUNIi021-A
(sAD5)
Donor diseases:
Alzheimer's Disease
ZZUi009-A
(ZZU-iPS-AD-PS1-001)
Donor diseases:
obsolete_Alzheimer's disease
STBCi011-A
(SFC803-03-01)
Donor's gene variants:
PSEN1
Donor diseases:
Alzheimer disease
STBCi011-B
(SFC803-03-02)
Donor's gene variants:
PSEN1
Donor diseases:
Alzheimer disease
STBCi011-C
(SFC803-03-08)
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PSEN1
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Alzheimer disease
STBCi012-A
(SFC805-03-01)
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PSEN1
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Alzheimer disease
STBCi256-A
(SFC144-03-02)
Donor's gene variants:
APOE
Donor diseases:
Alzheimer disease
STBCi012-B
(SFC805-03-02)
Donor's gene variants:
PSEN1
Donor diseases:
Alzheimer disease
STBCi012-C
(SFC805-03-03)
Donor's gene variants:
PSEN1
Donor diseases:
Alzheimer disease
STBCi013-A
(SFC807-03-01)
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PSEN1
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Alzheimer disease
STBCi013-B
(SFC807-03-04)
Donor's gene variants:
PSEN1
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Alzheimer disease
STBCi014-A
(SFC808-03-03)
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PSEN1
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Alzheimer disease
STBCi014-B
(SFC808-03-04)
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PSEN1
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Alzheimer disease
BIOTi001-A
(BIOT-7183-PSEN1)
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PSEN1
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obsolete_Alzheimer's disease
STBCi014-C
(SFC808-03-06)
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PSEN1
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STBCi264-A
(SFC142-03-01)
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Alzheimer disease
STBCi016-A
(SFC810-03-01)
Donor diseases:
Alzheimer disease
STBCi016-B
(SFC810-03-02)
Donor diseases:
Alzheimer disease
STBCi016-C
(SFC810-03-03)
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Alzheimer disease
UGOTSAi004-A
(N1-003iC3)
Donor diseases:
Alzheimer's Disease
UGOTSAi004-B
(N1-003iC4)
Donor diseases:
Alzheimer's Disease
STBCi032-A
(SFC042-03-01)
Donor diseases:
Alzheimer disease
STBCi032-B
(SFC042-03-03)
Donor diseases:
Alzheimer disease
LBi002-A
(PH-BL-002 Clone 2, iLB-272bfs2)
Donor's gene variants:
CD33, CD33, CD33, CD33
Donor diseases:
Alzheimer disease
LBi002-B
(PH-BL-002 Clone 9, iLB-272bfs9)
Donor's gene variants:
CD33, CD33, CD33, CD33
Donor diseases:
Alzheimer disease
LBi004-A
(PH-BL-204 Clone 210, iLB-278bfs210)
Donor's gene variants:
CD33, CD33, CD33, CD33
Donor diseases:
Alzheimer disease
LBi004-B
(PH-BL-204 Clone 211, iLB-278bfs211)
Donor's gene variants:
CD33, CD33, CD33, CD33
Donor diseases:
Alzheimer disease
Last update 18th April 2022
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Provider

Generator Institute of Basic Theory for Chinese Medicine (IBTCM)
Owner Institute of Basic Theory for Chinese Medicine (IBTCM)
Distributors
Derivation country China

External Databases

BioSamples SAMEA14096092
CLO CLO_0103852
Cellosaurus CVCL_C1Q0
Wikidata Q114311694

General Information

* Is the cell line readily obtainable for third parties?
No

Donor Information

General Donor Information

Sex female

Phenotype and Disease related information (Donor)

Diseases A disease was diagnosed.
Alzheimer's Disease
The donor is a carrier of a disease-associated mutation and affected.
Synonyms
  • Alzheimer's Disease
  • Alzheimer disease
  • Alzheimer Disease
  • Alzheimer dementia
  • Alzheimer's Dementia
  • Alzheimer's disease
  • Alzheimer's disease, unspecified
show more synonyms
Disease associated phenotypes
  • ApoE E3/E4

Karyotyping (Donor)

Has the donor karyotype been analysed?
Yes
46, XX karyotype
Karyotyping method: G-Banding

Other Genotyping (Donor)

Is there genome-wide genotyping or functional data available?
No

External Databases (Donor)

BioSamples SAMEA14096093

Ethics

Has informed consent been obtained from the donor of the embryo/tissue from which the pluripotent stem cells have been derived? Yes
Was the consent voluntarily given? Yes
Has the donor been informed that participation will not directly influence their personal treatment? Yes
Can you provide us with a copy of the Donor Information Sheet provided to the donor? Yes
Do you (Depositor/Provider) hold the original Donor Consent Form? Yes
Alternatives to consent are available? No
Is there other documentation provided to the donor for consenting purposes? No
Confirm that consent was obtained by a qualified professional Yes
Has the donor agreed to be re-contacted? Unknown
Has the donor been informed about how her/his data will be protected? Yes
Please indicate whether the data associated with the donated material has been pseudonymised or anonymised. anonymised
Does consent explicitly allow the derivation of pluripotent stem cells? Yes
Does consent prevent CELLS DERIVED FROM THE DONATED BIOSAMPLE from being made available to researchers anywhere in the world? No
How may genetic information associated with the cell line be accessed? Controlled Access
Will the donor expect to receive financial benefit, beyond reasonable expenses, in return for donating the biosample? No
Has a favourable opinion been obtained from a research ethics committee, or other ethics review panel, in relation to the Research Protocol including the consent provisions? Yes
Name of accrediting authority involved? The ethics committee of Institute of Basic Theory for Chinese Medicine, China Academy of Chinese Medical Sciences
Approval number 2018EC-KY-007
For generation of the cell line, who was the supplier of any recombined DNA vectors or commercial kits used?

hIPSC Derivation

General

Source cell type
renal epithelial cell
Source cell origin
Urine
The fluid that is excreted by the kidneys. It is stored in the bladder and discharged through the urethra.
Synonyms
  • Urine
  • Urinary System, Urine
  • urine
  • URINE
show more synonyms

Reprogramming method

Vector type Non-integrating
Vector Sendai virus
Is reprogramming vector detectable?
No

Vector free reprogramming

Other

Derived under xeno-free conditions
Unknown
Derived under GMP?
Unknown
Available as clinical grade?
Unknown

Culture Conditions

Surface coating Matrigel/Geltrex
Feeder cells
No
Passage method Enzyme-free cell dissociation
ReLeSR™ from STEMCELLTechnologies
Medium mTeSR™ 1
Has Rock inhibitor (Y27632) been used at passage previously with this cell line?
No
Has Rock inhibitor (Y27632) been used at cryo previously with this cell line?
No
Has Rock inhibitor (Y27632) been used at thaw previously with this cell line?
No

Characterisation

Analysis of Undifferentiated Cells
Marker Expressed Immunostaining RT-PCR FACS Enzymatic Assay Expression Profiles
Alkaline Phosphatase
Yes
POU5F1 (OCT-4)
Yes
SSEA-4
Yes
TRA 1-60
Yes
Score:
Marker Present Absent
mCpG
OCT4
Differentiation Potency
Gut Epithelium
Ont Id: NCIT_C12963
In vivo teratoma
Muscle Tissue
Ont Id: NCIT_C12435
In vivo teratoma
Hair Follicle
Ont Id: NCIT_C13317
In vivo teratoma

Genotyping

Karyotyping (Cell Line)

Has the cell line karyotype been analysed?
Yes
46, XX
Karyotyping method: G-Banding

Other Genotyping (Cell Line)