HPSI0916i-jejm_4

General

Cell Line

hPSCreg name WTSIi720-A
Cite as:
WTSIi720-A (RRID:CVCL_LM46)
Alternative name(s)
HPSI0916i-jejm_4
Cell line type Human induced pluripotent stem cell (hiPSC)
Similar lines
WTSIi470-A
(HPSI0516i-jory_9)
Donor diseases:
Hereditary ataxia
WTSIi621-B
(HPSI0916i-vorn_2)
Donor diseases:
Hereditary ataxia
WTSIi638-B
(HPSI0916i-zipi_5)
Donor diseases:
Hereditary ataxia
WTSIi502-A
(HPSI0216i-boho_3)
Donor diseases:
Hereditary ataxia
WTSIi568-A
(HPSI0216i-rihx_4)
Donor diseases:
Hereditary ataxia
WTSIi621-A
(HPSI0916i-vorn_5)
Donor diseases:
Hereditary ataxia
WTSIi638-A
(HPSI0916i-zipi_1)
Donor diseases:
Hereditary ataxia
WTSIi470-B
(HPSI0516i-jory_10)
Donor diseases:
Hereditary ataxia
WTSIi448-A
(HPSI0316i-muwv_3)
Donor diseases:
Hereditary ataxia
WTSIi459-A
(HPSI0516i-zukb_2)
Donor diseases:
Hereditary ataxia
WTSIi717-B
(HPSI0916i-helh_1)
Donor diseases:
Hereditary ataxia
WTSIi472-A
(HPSI0216i-vieg_5)
Donor diseases:
Hereditary ataxia
WTSIi699-B
(HPSI0916i-hikt_1)
Donor diseases:
Hereditary ataxia
WTSIi554-A
(HPSI0216i-dacv_6)
Donor diseases:
Hereditary ataxia
WTSIi472-B
(HPSI0216i-vieg_3)
Donor diseases:
Hereditary ataxia
WTSIi448-B
(HPSI0316i-muwv_6)
Donor diseases:
Hereditary ataxia
WTSIi459-B
(HPSI0516i-zukb_3)
Donor diseases:
Hereditary ataxia
WTSIi699-A
(HPSI0916i-hikt_2)
Donor diseases:
Hereditary ataxia
WTSIi717-A
(HPSI0916i-helh_6)
Donor diseases:
Hereditary ataxia
CHDIi001-A
(#1c8, CHDI-90002149)
Donor's gene variants:
HTT, HTT
Donor diseases:
Huntington disease
ZZUi010-A
(ZZU-iPS-AD-APP-001)
Donor diseases:
obsolete_Alzheimer's disease
CHDIi003-A
(#3c1, CHDI-90002151)
Donor's gene variants:
HTT, HTT
Donor diseases:
Huntington disease
CHDIi005-A
(#5c4, CHDI-90002153)
Donor's gene variants:
HTT, HTT
Donor diseases:
Huntington disease
CHDIi010-A
(#10c2, CHDI-90002158)
Donor's gene variants:
HTT, HTT
Donor diseases:
Huntington disease
CHDIi020-A
(#20c2, CHDI-90002168)
Donor's gene variants:
HTT, HTT
Donor diseases:
Huntington disease
CHDIi022-A
(#22c1, CHDI-90002170)
Donor's gene variants:
HTT, HTT
Donor diseases:
Huntington disease
CHDIi026-A
(#26c3, CHDI-90002174)
Donor's gene variants:
HTT, HTT
Donor diseases:
Huntington disease
CHDIi029-A
(#29c4, CHDI-90002177)
Donor's gene variants:
HTT, HTT
Donor diseases:
Huntington disease
CHDIi031-A
(#31c1, CHDI-90002179)
Donor's gene variants:
HTT, HTT
Donor diseases:
Huntington disease
CHDIi033-A
(#104c2, CHDI-90002181)
Donor's gene variants:
HTT, HTT
Donor diseases:
Huntington disease
CHDIi034-A
(#105c1, CHDI-90002182)
Donor's gene variants:
HTT, HTT
Donor diseases:
Huntington disease
CHDIi041-A
(#116c2, CHDI-90002189)
Donor's gene variants:
HTT, HTT
Donor diseases:
Huntington disease
CHDIi048-A
(#125c2, CHDI-90002196)
Donor's gene variants:
HTT, HTT
Donor diseases:
Huntington disease
CHDIi049-A
(#127c2, CHDI-90002197)
Donor's gene variants:
HTT, HTT
Donor diseases:
Huntington disease
CHDIi055-A
(#133c5, CHDI-90002203)
Donor's gene variants:
HTT, HTT
Donor diseases:
Huntington disease
STBCi004-B
(SFC832-03-06)
Donor's gene variants:
LRRK2
Donor diseases:
Parkinson disease
STBCi004-C
(SFC832-03-07)
Donor's gene variants:
LRRK2
Donor diseases:
Parkinson disease
ZZUi014-A
(ZZU-iPS-SCA3-002)
Donor diseases:
Spinocerebellar ataxia type 3
STBCi143-A
(SFC122-03-01)
Donor diseases:
Alzheimer disease
PFIZi013-A
(RCi215, RCFB59 C9)
Donor's gene variants:
TARDBP, TARDBP
Donor diseases:
Amyotrophic lateral sclerosis
HVRDi009-A
(29e SOD1 L144F, 29e)
Donor diseases:
obsolete_amyotrophic lateral sclerosis
WTSIi479-A
(HPSI0616i-beyk_6)
Donor diseases:
Spastic paraplegia
WTSIi498-A
(HPSI0616i-biln_2)
Donor diseases:
Spastic paraplegia
ZZUi009-A
(ZZU-iPS-AD-PS1-001)
Donor diseases:
obsolete_Alzheimer's disease
STBCi011-A
(SFC803-03-01)
Donor's gene variants:
PSEN1
Donor diseases:
Alzheimer disease
STBCi011-B
(SFC803-03-02)
Donor's gene variants:
PSEN1
Donor diseases:
Alzheimer disease
STBCi011-C
(SFC803-03-08)
Donor's gene variants:
PSEN1
Donor diseases:
Alzheimer disease
STBCi012-A
(SFC805-03-01)
Donor's gene variants:
PSEN1
Donor diseases:
Alzheimer disease
STBCi256-A
(SFC144-03-02)
Donor's gene variants:
APOE
Donor diseases:
Alzheimer disease
Last update 22nd May 2019
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Provider

Generator Wellcome Sanger Institute (WTSI)
Distributors

External Databases

HipSci HPSI0916i-jejm_4
BioSamples SAMEA103887294
Cellosaurus CVCL_LM46
Wikidata Q54891528

General Information

Projects
* Is the cell line readily obtainable for third parties?
Yes
Research use: allowed
Clinical use: not allowed
Commercial use: not allowed

Donor Information

General Donor Information

Sex female
Age of donor (at collection) 55-59
Ethnicity Caucasian

Phenotype and Disease related information (Donor)

Diseases A disease was diagnosed.

External Databases (Donor)

BioSamples SAMEA103884150

Ethics

Has informed consent been obtained from the donor of the embryo/tissue from which the pluripotent stem cells have been derived? Yes
Was the consent voluntarily given? Yes
Has the donor been informed that participation will not directly influence their personal treatment? Yes
Can you provide us with a copy of the Donor Information Sheet provided to the donor? No
Provide contact information of the holder of the original Donor Information Sheet: HipSci (http://www.hipsci.org/)
Do you (Depositor/Provider) hold the original Donor Consent Form? No
If you do not hold the Donor Consent Form, do you know who does? No
Contact information / weblink
Alternatives to consent
Alternative consent approval number
Is there other documentation provided to the donor for consenting purposes? No
Please indicate whether the data associated with the donated material has been pseudonymised or anonymised. anonymised
Does consent explicitly allow the derivation of pluripotent stem cells? Yes
Does consent expressly prevent the derivation of pluripotent stem cells? No
Details on restriction to research project
Does consent prevent CELLS DERIVED FROM THE DONATED BIOSAMPLE from being made available to researchers anywhere in the world? No
How may genetic information associated with the cell line be accessed?
Will the donor expect to receive financial benefit, beyond reasonable expenses, in return for donating the biosample? No
Please describe how access is provided:
Contact data, institution, or website:
Has a favourable opinion been obtained from a research ethics committee, or other ethics review panel, in relation to the Research Protocol including the consent provisions? No
Name of accrediting authority involved? name: Hampstead Research Ethics Committee; Approval Number: 13/LO/0171
Approval number
Has a favourable opinion been obtained from a research ethics committee, or other ethics review panel, in relation to the PROPOSED PROJECT, involving use of donated embryo/tissue or derived cells? Yes
Name of accrediting authority involved? Hampstead Research Ethics Committee
Approval number 13/LO/0171
Please describe:
Further constraints on use
For generation of the cell line, who was the supplier of any recombined DNA vectors or commercial kits used?
Constraints for use or distribution

hIPSC Derivation

General

Source cell type
A connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules. Flattened and irregular in outline with branching processes; appear fusiform or spindle-shaped.; These cells may be vimentin-positive, fibronectin-positive, fsp1-positive, MMP-1-positive, collagen I-positive, collagen III-positive, and alpha-SMA-negative.
Source cell origin
Any portion of the organ that covers that body and consists of a layer of epidermis and a layer of dermis.
Synonyms
  • portion of skin
  • region of skin
  • skin
  • skin region
  • skin zone
show more synonyms
Age of donor (at collection) 55-59
Collected in 2016
Source cell line vendor University College London

Reprogramming method

Vector type Non-integrating
Vector Sendai virus
Notes on reprogramming vector detection CytoTune 2

Vector free reprogramming

Other

Derived under xeno-free conditions
Unknown
Derived under GMP?
Unknown
Available as clinical grade?
Unknown

Culture Conditions

Surface coating Vitronectin
Feeder cells
No
Passage method Enzyme-free cell dissociation
EDTA
CO2 Concentration 5 %
Medium TeSR™ E8™

Characterisation

Analysis of Undifferentiated Cells
Pluripotency Score Novelty Score
28.663 1.25

Certificate of Analysis

Is there a certificate of analysis available?
Yes

Genotyping

Karyotyping (Cell Line)

Has the cell line karyotype been analysed?
No

Other Genotyping (Cell Line)

Is there genome-wide genotyping or functional data available?
Yes